---
_id: '3806'
abstract:
- lang: eng
text: To probe exocytosis at a cortical glutamatergic synapse, we made capacitance
measurements in whole-cell recorded hippocampal mossy fiber terminals. Evaluation
of different methods by using a morphology-based equivalent electrical model revealed
that quantitative capacitance measurements are possible in this presynaptic structure.
Voltage pulses leading to presynaptic Ca2+ inflow evoked large capacitance signals
that showed saturation with increasing pulse duration. The mean peak capacitance
increase was 100 fF, corresponding to a pool of approximately 1,400 releasable
vesicles. Thus hippocampal mossy fiber synapses have a vesicular "maxipool."
Large pool size and rapid vesicle recycling may underlie the uniquely large extent
of activity-dependent plasticity in this synapse.
author:
- first_name: Stefan
full_name: Hallermann, Stefan
last_name: Hallermann
- first_name: Christian
full_name: Pawlu, Christian
last_name: Pawlu
- first_name: Peter M
full_name: Peter Jonas
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Manfred
full_name: Heckmann, Manfred
last_name: Heckmann
citation:
ama: Hallermann S, Pawlu C, Jonas PM, Heckmann M. A large pool of releasable vesicles
in a cortical glutamatergic synapse. PNAS. 2003;100(15):8975-8980. doi:10.1073/pnas.1432836100
apa: Hallermann, S., Pawlu, C., Jonas, P. M., & Heckmann, M. (2003). A large
pool of releasable vesicles in a cortical glutamatergic synapse. PNAS.
National Academy of Sciences. https://doi.org/10.1073/pnas.1432836100
chicago: Hallermann, Stefan, Christian Pawlu, Peter M Jonas, and Manfred Heckmann.
“A Large Pool of Releasable Vesicles in a Cortical Glutamatergic Synapse.” PNAS.
National Academy of Sciences, 2003. https://doi.org/10.1073/pnas.1432836100.
ieee: S. Hallermann, C. Pawlu, P. M. Jonas, and M. Heckmann, “A large pool of releasable
vesicles in a cortical glutamatergic synapse,” PNAS, vol. 100, no. 15.
National Academy of Sciences, pp. 8975–80, 2003.
ista: Hallermann S, Pawlu C, Jonas PM, Heckmann M. 2003. A large pool of releasable
vesicles in a cortical glutamatergic synapse. PNAS. 100(15), 8975–80.
mla: Hallermann, Stefan, et al. “A Large Pool of Releasable Vesicles in a Cortical
Glutamatergic Synapse.” PNAS, vol. 100, no. 15, National Academy of Sciences,
2003, pp. 8975–80, doi:10.1073/pnas.1432836100.
short: S. Hallermann, C. Pawlu, P.M. Jonas, M. Heckmann, PNAS 100 (2003) 8975–80.
date_created: 2018-12-11T12:05:16Z
date_published: 2003-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:20Z
day: '01'
doi: 10.1073/pnas.1432836100
extern: 1
intvolume: ' 100'
issue: '15'
month: '01'
page: 8975 - 80
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '2405'
quality_controlled: 0
status: public
title: A large pool of releasable vesicles in a cortical glutamatergic synapse
type: journal_article
volume: 100
year: '2003'
...