--- _id: '3806' abstract: - lang: eng text: To probe exocytosis at a cortical glutamatergic synapse, we made capacitance measurements in whole-cell recorded hippocampal mossy fiber terminals. Evaluation of different methods by using a morphology-based equivalent electrical model revealed that quantitative capacitance measurements are possible in this presynaptic structure. Voltage pulses leading to presynaptic Ca2+ inflow evoked large capacitance signals that showed saturation with increasing pulse duration. The mean peak capacitance increase was 100 fF, corresponding to a pool of approximately 1,400 releasable vesicles. Thus hippocampal mossy fiber synapses have a vesicular "maxipool." Large pool size and rapid vesicle recycling may underlie the uniquely large extent of activity-dependent plasticity in this synapse. author: - first_name: Stefan full_name: Hallermann, Stefan last_name: Hallermann - first_name: Christian full_name: Pawlu, Christian last_name: Pawlu - first_name: Peter M full_name: Peter Jonas id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Manfred full_name: Heckmann, Manfred last_name: Heckmann citation: ama: Hallermann S, Pawlu C, Jonas PM, Heckmann M. A large pool of releasable vesicles in a cortical glutamatergic synapse. PNAS. 2003;100(15):8975-8980. doi:10.1073/pnas.1432836100 apa: Hallermann, S., Pawlu, C., Jonas, P. M., & Heckmann, M. (2003). A large pool of releasable vesicles in a cortical glutamatergic synapse. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.1432836100 chicago: Hallermann, Stefan, Christian Pawlu, Peter M Jonas, and Manfred Heckmann. “A Large Pool of Releasable Vesicles in a Cortical Glutamatergic Synapse.” PNAS. National Academy of Sciences, 2003. https://doi.org/10.1073/pnas.1432836100. ieee: S. Hallermann, C. Pawlu, P. M. Jonas, and M. Heckmann, “A large pool of releasable vesicles in a cortical glutamatergic synapse,” PNAS, vol. 100, no. 15. National Academy of Sciences, pp. 8975–80, 2003. ista: Hallermann S, Pawlu C, Jonas PM, Heckmann M. 2003. A large pool of releasable vesicles in a cortical glutamatergic synapse. PNAS. 100(15), 8975–80. mla: Hallermann, Stefan, et al. “A Large Pool of Releasable Vesicles in a Cortical Glutamatergic Synapse.” PNAS, vol. 100, no. 15, National Academy of Sciences, 2003, pp. 8975–80, doi:10.1073/pnas.1432836100. short: S. Hallermann, C. Pawlu, P.M. Jonas, M. Heckmann, PNAS 100 (2003) 8975–80. date_created: 2018-12-11T12:05:16Z date_published: 2003-01-01T00:00:00Z date_updated: 2021-01-12T07:52:20Z day: '01' doi: 10.1073/pnas.1432836100 extern: 1 intvolume: ' 100' issue: '15' month: '01' page: 8975 - 80 publication: PNAS publication_status: published publisher: National Academy of Sciences publist_id: '2405' quality_controlled: 0 status: public title: A large pool of releasable vesicles in a cortical glutamatergic synapse type: journal_article volume: 100 year: '2003' ...