A large pool of releasable vesicles in a cortical glutamatergic synapse

S. Hallermann, C. Pawlu, P.M. Jonas, M. Heckmann, PNAS 100 (2003) 8975–80.

Download
No fulltext has been uploaded. References only!

Journal Article | Published
Author
; ; ;
Abstract
To probe exocytosis at a cortical glutamatergic synapse, we made capacitance measurements in whole-cell recorded hippocampal mossy fiber terminals. Evaluation of different methods by using a morphology-based equivalent electrical model revealed that quantitative capacitance measurements are possible in this presynaptic structure. Voltage pulses leading to presynaptic Ca2+ inflow evoked large capacitance signals that showed saturation with increasing pulse duration. The mean peak capacitance increase was 100 fF, corresponding to a pool of approximately 1,400 releasable vesicles. Thus hippocampal mossy fiber synapses have a vesicular "maxipool." Large pool size and rapid vesicle recycling may underlie the uniquely large extent of activity-dependent plasticity in this synapse.
Publishing Year
Date Published
2003-01-01
Journal Title
PNAS
Volume
100
Issue
15
Page
8975 - 80
IST-REx-ID

Cite this

Hallermann S, Pawlu C, Jonas PM, Heckmann M. A large pool of releasable vesicles in a cortical glutamatergic synapse. PNAS. 2003;100(15):8975-8980. doi:10.1073/pnas.1432836100
Hallermann, S., Pawlu, C., Jonas, P. M., & Heckmann, M. (2003). A large pool of releasable vesicles in a cortical glutamatergic synapse. PNAS, 100(15), 8975–8980. https://doi.org/10.1073/pnas.1432836100
Hallermann, Stefan, Christian Pawlu, Peter M Jonas, and Manfred Heckmann. “A Large Pool of Releasable Vesicles in a Cortical Glutamatergic Synapse.” PNAS 100, no. 15 (2003): 8975–80. https://doi.org/10.1073/pnas.1432836100.
S. Hallermann, C. Pawlu, P. M. Jonas, and M. Heckmann, “A large pool of releasable vesicles in a cortical glutamatergic synapse,” PNAS, vol. 100, no. 15, pp. 8975–80, 2003.
Hallermann S, Pawlu C, Jonas PM, Heckmann M. 2003. A large pool of releasable vesicles in a cortical glutamatergic synapse. PNAS. 100(15), 8975–80.
Hallermann, Stefan, et al. “A Large Pool of Releasable Vesicles in a Cortical Glutamatergic Synapse.” PNAS, vol. 100, no. 15, National Academy of Sciences, 2003, pp. 8975–80, doi:10.1073/pnas.1432836100.

Export

Marked Publications

Open Data IST Research Explorer

Search this title in

Google Scholar