--- res: bibo_abstract: - 'Genomes of closely-related species or populations often display localized regions of enhanced relative sequence divergence, termed genomic islands. It has been proposed that these islands arise through selective sweeps and/or barriers to gene flow. Here, we genetically dissect a genomic island that controls flower color pattern differences between two subspecies of Antirrhinum majus, A.m.striatum and A.m.pseudomajus, and relate it to clinal variation across a natural hybrid zone. We show that selective sweeps likely raised relative divergence at two tightly-linked MYB-like transcription factors, leading to distinct flower patterns in the two subspecies. The two patterns provide alternate floral guides and create a strong barrier to gene flow where populations come into contact. This barrier affects the selected flower color genes and tightlylinked loci, but does not extend outside of this domain, allowing gene flow to lower relative divergence for the rest of the chromosome. Thus, both selective sweeps and barriers to gene flow play a role in shaping genomic islands: sweeps cause elevation in relative divergence, while heterogeneous gene flow flattens the surrounding "sea," making the island of divergence stand out. By showing how selective sweeps establish alternative adaptive phenotypes that lead to barriers to gene flow, our study sheds light on possible mechanisms leading to reproductive isolation and speciation.@eng' bibo_authorlist: - foaf_Person: foaf_givenName: Hugo foaf_name: Tavares, Hugo foaf_surname: Tavares - foaf_Person: foaf_givenName: Annabel foaf_name: Whitley, Annabel foaf_surname: Whitley - foaf_Person: foaf_givenName: David foaf_name: Field, David foaf_surname: Field foaf_workInfoHomepage: http://www.librecat.org/personId=419049E2-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-4014-8478 - foaf_Person: foaf_givenName: Desmond foaf_name: Bradley, Desmond foaf_surname: Bradley - foaf_Person: foaf_givenName: Matthew foaf_name: Couchman, Matthew foaf_surname: Couchman - foaf_Person: foaf_givenName: Lucy foaf_name: Copsey, Lucy foaf_surname: Copsey - foaf_Person: foaf_givenName: Joane foaf_name: Elleouet, Joane foaf_surname: Elleouet - foaf_Person: foaf_givenName: Monique foaf_name: Burrus, Monique foaf_surname: Burrus - foaf_Person: foaf_givenName: Christophe foaf_name: Andalo, Christophe foaf_surname: Andalo - foaf_Person: foaf_givenName: Miaomiao foaf_name: Li, Miaomiao foaf_surname: Li - foaf_Person: foaf_givenName: Qun foaf_name: Li, Qun foaf_surname: Li - foaf_Person: foaf_givenName: Yongbiao foaf_name: Xue, Yongbiao foaf_surname: Xue - foaf_Person: foaf_givenName: Alexandra B foaf_name: Rebocho, Alexandra B foaf_surname: Rebocho - foaf_Person: foaf_givenName: Nicholas H foaf_name: Barton, Nicholas H foaf_surname: Barton foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8548-5240 - foaf_Person: foaf_givenName: Enrico foaf_name: Coen, Enrico foaf_surname: Coen bibo_doi: 10.1073/pnas.1801832115 bibo_issue: '43' bibo_volume: 115 dct_date: 2018^xs_gYear dct_identifier: - UT:000448040500065 dct_isPartOf: - http://id.crossref.org/issn/00278424 dct_language: eng dct_publisher: National Academy of Sciences@ dct_title: Selection and gene flow shape genomic islands that control floral guides@ fabio_hasPubmedId: '30297406' ...