---
_id: '3789'
abstract:
- lang: eng
text: 'The development of multicellular organisms is dependent on the tight coordination
between tissue growth and morphogenesis. The stereotypical orientation of cell
divisions has been proposed to be a fundamental mechanism by which proliferating
and growing tissues take shape. However, the actual contribution of stereotypical
division orientation (SDO) to tissue morphogenesis is unclear. In zebrafish, cell
divisions with stereotypical orientation have been implicated in both body-axis
elongation and neural rod formation [1, 2], although there is little direct evidence
for a critical function of SDO in either of these processes. Here we show that
SDO is required for formation of the neural rod midline during neurulation but
dispensable for elongation of the body axis during gastrulation. Our data indicate
that SDO during both gastrulation and neurulation is dependent on the noncanonical
Wnt receptor Frizzled 7 (Fz7) and that interfering with cell division orientation
leads to severe defects in neural rod midline formation but not body-axis elongation.
These findings suggest a novel function for Fz7-controlled cell division orientation
in neural rod midline formation during neurulation. '
acknowledgement: "This work was supported by grants from the Fundacion Caja Madrid
to E.Q.H. and the Institute of Science and Technology Austria, the Max-Planck-Society,
and the Deutsche Forschungsgemeinschaft to C.P.H.\r\nWe are grateful to Jon Clarke,
Andy Oates, and Garrett Greenan for reading earlier versions of this manuscript.
We thank J. Peychl, H. Ibarra, and P. Pitrone for excellent assistance and advice
in multi-photon microscopy and D. White for assistance during the image-processing
steps. We also thank D. Panhans for technical assistance, the whole Heisenberg laboratory
for useful comments and discussions, and E. Lehmann, J. Hückmann, and G. Junghans
for excellent fish care. "
author:
- first_name: Elena
full_name: Quesada-Hernández, Elena
id: EA35229E-E909-11E9-8DF8-C90C5D5AF86E
last_name: Quesada-Hernández
- first_name: Luca
full_name: Caneparo, Luca
last_name: Caneparo
- first_name: Sylvia
full_name: Schneider, Sylvia
id: 1FAC36B0-E90A-11E9-9D2F-EF31CE0C9C2F
last_name: Schneider
- first_name: Sylke
full_name: Winkler, Sylke
last_name: Winkler
- first_name: Michael
full_name: Liebling, Michael
last_name: Liebling
- first_name: Scott
full_name: Fraser, Scott
last_name: Fraser
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Quesada-Hernández E, Caneparo L, Schneider S, et al. Stereotypical cell division
orientation controls neural rod midline formation in zebrafish. Current Biology.
2010;20(21):1966-1972. doi:10.1016/j.cub.2010.10.009
apa: Quesada-Hernández, E., Caneparo, L., Schneider, S., Winkler, S., Liebling,
M., Fraser, S., & Heisenberg, C.-P. J. (2010). Stereotypical cell division
orientation controls neural rod midline formation in zebrafish. Current Biology.
Cell Press. https://doi.org/10.1016/j.cub.2010.10.009
chicago: Quesada-Hernández, Elena, Luca Caneparo, Sylvia Schneider, Sylke Winkler,
Michael Liebling, Scott Fraser, and Carl-Philipp J Heisenberg. “Stereotypical
Cell Division Orientation Controls Neural Rod Midline Formation in Zebrafish.”
Current Biology. Cell Press, 2010. https://doi.org/10.1016/j.cub.2010.10.009.
ieee: E. Quesada-Hernández et al., “Stereotypical cell division orientation
controls neural rod midline formation in zebrafish,” Current Biology, vol.
20, no. 21. Cell Press, pp. 1966–1972, 2010.
ista: Quesada-Hernández E, Caneparo L, Schneider S, Winkler S, Liebling M, Fraser
S, Heisenberg C-PJ. 2010. Stereotypical cell division orientation controls neural
rod midline formation in zebrafish. Current Biology. 20(21), 1966–1972.
mla: Quesada-Hernández, Elena, et al. “Stereotypical Cell Division Orientation Controls
Neural Rod Midline Formation in Zebrafish.” Current Biology, vol. 20, no.
21, Cell Press, 2010, pp. 1966–72, doi:10.1016/j.cub.2010.10.009.
short: E. Quesada-Hernández, L. Caneparo, S. Schneider, S. Winkler, M. Liebling,
S. Fraser, C.-P.J. Heisenberg, Current Biology 20 (2010) 1966–1972.
date_created: 2018-12-11T12:05:11Z
date_published: 2010-11-09T00:00:00Z
date_updated: 2021-01-12T07:52:12Z
day: '09'
department:
- _id: CaHe
doi: 10.1016/j.cub.2010.10.009
intvolume: ' 20'
issue: '21'
language:
- iso: eng
month: '11'
oa_version: None
page: 1966 - 1972
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '2438'
quality_controlled: '1'
scopus_import: 1
status: public
title: Stereotypical cell division orientation controls neural rod midline formation
in zebrafish
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2010'
...