--- res: bibo_abstract: - The development of multicellular organisms is dependent on the tight coordination between tissue growth and morphogenesis. The stereotypical orientation of cell divisions has been proposed to be a fundamental mechanism by which proliferating and growing tissues take shape. However, the actual contribution of stereotypical division orientation (SDO) to tissue morphogenesis is unclear. In zebrafish, cell divisions with stereotypical orientation have been implicated in both body-axis elongation and neural rod formation [1, 2], although there is little direct evidence for a critical function of SDO in either of these processes. Here we show that SDO is required for formation of the neural rod midline during neurulation but dispensable for elongation of the body axis during gastrulation. Our data indicate that SDO during both gastrulation and neurulation is dependent on the noncanonical Wnt receptor Frizzled 7 (Fz7) and that interfering with cell division orientation leads to severe defects in neural rod midline formation but not body-axis elongation. These findings suggest a novel function for Fz7-controlled cell division orientation in neural rod midline formation during neurulation. @eng bibo_authorlist: - foaf_Person: foaf_givenName: Elena foaf_name: Quesada-Hernández, Elena foaf_surname: Quesada-Hernández foaf_workInfoHomepage: http://www.librecat.org/personId=EA35229E-E909-11E9-8DF8-C90C5D5AF86E - foaf_Person: foaf_givenName: Luca foaf_name: Caneparo, Luca foaf_surname: Caneparo - foaf_Person: foaf_givenName: Sylvia foaf_name: Schneider, Sylvia foaf_surname: Schneider foaf_workInfoHomepage: http://www.librecat.org/personId=1FAC36B0-E90A-11E9-9D2F-EF31CE0C9C2F - foaf_Person: foaf_givenName: Sylke foaf_name: Winkler, Sylke foaf_surname: Winkler - foaf_Person: foaf_givenName: Michael foaf_name: Liebling, Michael foaf_surname: Liebling - foaf_Person: foaf_givenName: Scott foaf_name: Fraser, Scott foaf_surname: Fraser - foaf_Person: foaf_givenName: Carl-Philipp J foaf_name: Heisenberg, Carl-Philipp J foaf_surname: Heisenberg foaf_workInfoHomepage: http://www.librecat.org/personId=39427864-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-0912-4566 bibo_doi: 10.1016/j.cub.2010.10.009 bibo_issue: '21' bibo_volume: 20 dct_date: 2010^xs_gYear dct_language: eng dct_publisher: Cell Press@ dct_title: Stereotypical cell division orientation controls neural rod midline formation in zebrafish@ ...