Interdependence of behavioural variability and response to small stimuli in bacteria

H. Park, W. Pontius, C.C. Guet, J. Marko, T. Emonet, P. Cluzel, Nature 468 (2010) 819–823.


Journal Article | Published
Author
; ; ; ; ;
Abstract
The chemotaxis signalling network in Escherichia coli that controls the locomotion of bacteria is a classic model system for signal transduction1, 2. This pathway modulates the behaviour of flagellar motors to propel bacteria towards sources of chemical attractants. Although this system relaxes to a steady state in response to environmental changes, the signalling events within the chemotaxis network are noisy and cause large temporal variations of the motor behaviour even in the absence of stimulus3. That the same signalling network governs both behavioural variability and cellular response raises the question of whether these two traits are independent. Here, we experimentally establish a fluctuation–response relationship in the chemotaxis system of living bacteria. Using this relationship, we demonstrate the possibility of inferring the cellular response from the behavioural variability measured before stimulus. In monitoring the pre- and post-stimulus switching behaviour of individual bacterial motors, we found that variability scales linearly with the response time for different functioning states of the cell. This study highlights that the fundamental relationship between fluctuation and response is not constrained to physical systems at thermodynamic equilibrium4 but is extensible to living cells5. Such a relationship not only implies that behavioural variability and cellular response can be coupled traits, but it also provides a general framework within which we can examine how the selection of a network design shapes this interdependence
Publishing Year
Date Published
2010-12-09
Journal Title
Nature
Volume
468
Page
819 - 823
IST-REx-ID

Cite this

Park H, Pontius W, Guet CC, Marko J, Emonet T, Cluzel P. Interdependence of behavioural variability and response to small stimuli in bacteria. Nature. 2010;468:819-823. doi:10.1038/nature09551
Park, H., Pontius, W., Guet, C. C., Marko, J., Emonet, T., & Cluzel, P. (2010). Interdependence of behavioural variability and response to small stimuli in bacteria. Nature, 468, 819–823. https://doi.org/10.1038/nature09551
Park, Heungwon, William Pontius, Calin C Guet, John Marko, Thierry Emonet, and Philippe Cluzel. “Interdependence of Behavioural Variability and Response to Small Stimuli in Bacteria.” Nature 468 (2010): 819–23. https://doi.org/10.1038/nature09551.
H. Park, W. Pontius, C. C. Guet, J. Marko, T. Emonet, and P. Cluzel, “Interdependence of behavioural variability and response to small stimuli in bacteria,” Nature, vol. 468, pp. 819–823, 2010.
Park H, Pontius W, Guet CC, Marko J, Emonet T, Cluzel P. 2010. Interdependence of behavioural variability and response to small stimuli in bacteria. Nature. 468, 819–823.
Park, Heungwon, et al. “Interdependence of Behavioural Variability and Response to Small Stimuli in Bacteria.” Nature, vol. 468, Nature Publishing Group, 2010, pp. 819–23, doi:10.1038/nature09551.

Link(s) to Main File(s)
Access Level
OA Open Access

Export

Marked Publications

Open Data IST Research Explorer

Search this title in

Google Scholar