Diffusion, dimensionality, and noise in transcriptional regulation

G. Tkacik, W. Bialek, Physical Review E Statistical Nonlinear and Soft Matter Physics 79 (2009).

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Abstract
The precision of biochemical signaling is limited by randomness in the diffusive arrival of molecules at their targets. For proteins binding to specific sites on DNA and regulating transcription, the ability of the proteins to diffuse in one dimension by sliding along the length of the DNA, in addition to their diffusion in bulk solution, would seem to generate a larger target for DNA binding, consequently reducing the noise in the occupancy of the regulatory site. Here we show that this effect is largely canceled by the enhanced temporal correlations in one-dimensional diffusion. With realistic parameters, sliding along DNA has surprisingly little effect on the physical limits to the precision of transcriptional regulation.
Publishing Year
Date Published
2009-05-04
Journal Title
Physical Review E Statistical Nonlinear and Soft Matter Physics
Volume
79
Issue
5
IST-REx-ID

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Tkacik G, Bialek W. Diffusion, dimensionality, and noise in transcriptional regulation. Physical Review E Statistical Nonlinear and Soft Matter Physics. 2009;79(5). doi:10.1103/PhysRevE.79.051901
Tkacik, G., & Bialek, W. (2009). Diffusion, dimensionality, and noise in transcriptional regulation. Physical Review E Statistical Nonlinear and Soft Matter Physics, 79(5). https://doi.org/10.1103/PhysRevE.79.051901
Tkacik, Gasper, and William Bialek. “Diffusion, Dimensionality, and Noise in Transcriptional Regulation.” Physical Review E Statistical Nonlinear and Soft Matter Physics 79, no. 5 (2009). https://doi.org/10.1103/PhysRevE.79.051901.
G. Tkacik and W. Bialek, “Diffusion, dimensionality, and noise in transcriptional regulation,” Physical Review E Statistical Nonlinear and Soft Matter Physics, vol. 79, no. 5, 2009.
Tkacik G, Bialek W. 2009. Diffusion, dimensionality, and noise in transcriptional regulation. Physical Review E Statistical Nonlinear and Soft Matter Physics. 79(5).
Tkacik, Gasper, and William Bialek. “Diffusion, Dimensionality, and Noise in Transcriptional Regulation.” Physical Review E Statistical Nonlinear and Soft Matter Physics, vol. 79, no. 5, American Institute of Physics, 2009, doi:10.1103/PhysRevE.79.051901.

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