Information flow and optimization in transcriptional regulation

G. Tkacik, C. Callan, W. Bialek, PNAS 105 (2008) 12265–12270.


Journal Article | Published
Author
; ;
Abstract
In the simplest view of transcriptional regulation, the expression of a gene is turned on or off by changes in the concentration of a transcription factor (TF). We use recent data on noise levels in gene expression to show that it should be possible to transmit much more than just one regulatory bit. Realizing this optimal information capacity would require that the dynamic range of TF concentrations used by the cell, the input/output relation of the regulatory module, and the noise in gene expression satisfy certain matching relations, which we derive. These results provide parameter-free, quantitative predictions connecting independently measurable quantities. Although we have considered only the simplified problem of a single gene responding to a single TF, we find that these predictions are in surprisingly good agreement with recent experiments on the Bicoid/Hunchback system in the early Drosophila embryo and that this system achieves approximately 90% of its theoretical maximum information transmission.
Publishing Year
Date Published
2008-01-01
Journal Title
PNAS
Acknowledgement
P50 GM071508/GM/NIGMS NIH HHS/United States; R01 GM077599/GM/NIGMS NIH HHS/United States
Volume
105
Issue
34
Page
12265 - 12270
IST-REx-ID

Cite this

Tkacik G, Callan C, Bialek W. Information flow and optimization in transcriptional regulation. PNAS. 2008;105(34):12265-12270. doi:10.1073/pnas.0806077105
Tkacik, G., Callan, C., & Bialek, W. (2008). Information flow and optimization in transcriptional regulation. PNAS, 105(34), 12265–12270. https://doi.org/10.1073/pnas.0806077105
Tkacik, Gasper, Curtis Callan, and William Bialek. “Information Flow and Optimization in Transcriptional Regulation.” PNAS 105, no. 34 (2008): 12265–70. https://doi.org/10.1073/pnas.0806077105.
G. Tkacik, C. Callan, and W. Bialek, “Information flow and optimization in transcriptional regulation,” PNAS, vol. 105, no. 34, pp. 12265–12270, 2008.
Tkacik G, Callan C, Bialek W. 2008. Information flow and optimization in transcriptional regulation. PNAS. 105(34), 12265–12270.
Tkacik, Gasper, et al. “Information Flow and Optimization in Transcriptional Regulation.” PNAS, vol. 105, no. 34, National Academy of Sciences, 2008, pp. 12265–70, doi:10.1073/pnas.0806077105.

Link(s) to Main File(s)
Access Level
OA Open Access

Export

Marked Publications

Open Data IST Research Explorer

Search this title in

Google Scholar