---
_id: '3728'
abstract:
- lang: eng
text: Mechanical unfolding of single bacteriorhodopsins from a membrane bilayer
is studied using molecular dynamics simulations. The initial conformation of the
lipid membrane is determined through all-atom simulations and then its coarse-grained
representation is used in the studies of stretching. A Go-like model with a realistic
contact map and with Lennard–Jones contact interactions is applied to model the
protein–membrane system. The model qualitatively reproduces the experimentally
observed differences between force-extension patterns obtained on bacteriorhodopsin
at different temperatures and predicts a lack of symmetry in the choice of the
terminus to pull by. It also illustrates the decisive role of the interactions
of the protein with the membrane in determining the force pattern and thus the
stability of transmembrane proteins.
author:
- first_name: Marek
full_name: Cieplak, Marek
last_name: Cieplak
- first_name: Sławomir
full_name: Filipek, Sławomir
last_name: Filipek
- first_name: Harald L
full_name: Harald Janovjak
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
- first_name: Krystiana
full_name: Krzysko, Krystiana A
last_name: Krzysko
citation:
ama: 'Cieplak M, Filipek S, Janovjak HL, Krzysko K. Pulling single bacteriorhodopsin
out of a membrane: Comparison of simulation and experiment. Biochimica et Biophysica
Acta (BBA) - Biomembranes. 2006;1758(4):537-544. doi:10.1016/j.bbamem.2006.03.028'
apa: 'Cieplak, M., Filipek, S., Janovjak, H. L., & Krzysko, K. (2006). Pulling
single bacteriorhodopsin out of a membrane: Comparison of simulation and experiment.
Biochimica et Biophysica Acta (BBA) - Biomembranes. Elsevier. https://doi.org/10.1016/j.bbamem.2006.03.028'
chicago: 'Cieplak, Marek, Sławomir Filipek, Harald L Janovjak, and Krystiana Krzysko.
“Pulling Single Bacteriorhodopsin out of a Membrane: Comparison of Simulation
and Experiment.” Biochimica et Biophysica Acta (BBA) - Biomembranes. Elsevier,
2006. https://doi.org/10.1016/j.bbamem.2006.03.028.'
ieee: 'M. Cieplak, S. Filipek, H. L. Janovjak, and K. Krzysko, “Pulling single bacteriorhodopsin
out of a membrane: Comparison of simulation and experiment,” Biochimica et
Biophysica Acta (BBA) - Biomembranes, vol. 1758, no. 4. Elsevier, pp. 537–544,
2006.'
ista: 'Cieplak M, Filipek S, Janovjak HL, Krzysko K. 2006. Pulling single bacteriorhodopsin
out of a membrane: Comparison of simulation and experiment. Biochimica et Biophysica
Acta (BBA) - Biomembranes. 1758(4), 537–544.'
mla: 'Cieplak, Marek, et al. “Pulling Single Bacteriorhodopsin out of a Membrane:
Comparison of Simulation and Experiment.” Biochimica et Biophysica Acta (BBA)
- Biomembranes, vol. 1758, no. 4, Elsevier, 2006, pp. 537–44, doi:10.1016/j.bbamem.2006.03.028.'
short: M. Cieplak, S. Filipek, H.L. Janovjak, K. Krzysko, Biochimica et Biophysica
Acta (BBA) - Biomembranes 1758 (2006) 537–544.
date_created: 2018-12-11T12:04:50Z
date_published: 2006-04-01T00:00:00Z
date_updated: 2021-01-12T07:51:46Z
day: '01'
doi: 10.1016/j.bbamem.2006.03.028
extern: 1
intvolume: ' 1758'
issue: '4'
month: '04'
page: 537 - 544
publication: Biochimica et Biophysica Acta (BBA) - Biomembranes
publication_status: published
publisher: Elsevier
publist_id: '2502'
quality_controlled: 0
status: public
title: 'Pulling single bacteriorhodopsin out of a membrane: Comparison of simulation
and experiment'
type: journal_article
volume: 1758
year: '2006'
...