---
_id: '3718'
abstract:
- lang: eng
text: Long-term depression (LTD) is a form of synaptic plasticity that may contribute
to information storage in the central nervous system. Here we report that LTD
can be elicited in layer 5 pyramidal neurons of the rat prefrontal cortex by pairing
low frequency stimulation with a modest postsynaptic depolarization. The induction
of LTD required the activation of both metabotropic glutamate receptors of the
mGlu1 subtype and voltage-sensitive Ca(2+) channels (VSCCs) of the T/R, P/Q and
N types, leading to the stimulation of intracellular inositol trisphosphate (IP3)
receptors by IP3 and Ca(2+). The subsequent release of Ca(2+) from intracellular
stores activated the protein phosphatase cascade involving calcineurin and protein
phosphatase 1. The activation of purinergic P2Y(1) receptors blocked LTD. This
effect was prevented by P2Y(1) receptor antagonists and was absent in mice lacking
P2Y(1) but not P2Y(2) receptors. We also found that activation of P2Y(1) receptors
inhibits Ca(2+) transients via VSCCs in the apical dendrites and spines of pyramidal
neurons. In addition, we show that the release of ATP under hypoxia is able to
inhibit LTD by acting on postsynaptic P2Y(1) receptors. In conclusion, these data
suggest that the reduction of Ca(2+) influx via VSCCs caused by the activation
of P2Y(1) receptors by ATP is the possible mechanism for the inhibition of LTD
in prefrontal cortex.
acknowledgement: " The financial support of the Deutsche Forschungsgemeinschaft (IL
20/12-1, KI 677/2-4) is gratefully acknowledged.\r\nWe thank B. H. Koller (Department
of Genetics and Molecular Biology, University of North Carolina at Chapel Hill,
NC, USA) for the generous supply of P2Y1−/− and P2Y2−/− mice. We are grateful to
Dr. A. Schulz for reanalysing the genotype of the P2Y1−/− mice. The authors thank
P. Jonas and U. Heinemann for many helpful comments and A-K. Krause, L Feige and
M. Eberts for their excellent technical support."
author:
- first_name: José
full_name: Guzmán, José
id: 30CC5506-F248-11E8-B48F-1D18A9856A87
last_name: Guzmán
- first_name: Hartmut
full_name: Schmidt, Hartmut
last_name: Schmidt
- first_name: Heike
full_name: Franke, Heike
last_name: Franke
- first_name: Ute
full_name: Krügel, Ute
last_name: Krügel
- first_name: Jens
full_name: Eilers, Jens
last_name: Eilers
- first_name: Peter
full_name: Illes, Peter
last_name: Illes
- first_name: Zoltan
full_name: Gerevich, Zoltan
last_name: Gerevich
citation:
ama: Guzmán J, Schmidt H, Franke H, et al. P2Y1 receptors inhibit long-term depression
in the prefrontal cortex. Neuropharmacology. 2010;59(6):406-415. doi:10.1016/j.neuropharm.2010.05.013
apa: Guzmán, J., Schmidt, H., Franke, H., Krügel, U., Eilers, J., Illes, P., &
Gerevich, Z. (2010). P2Y1 receptors inhibit long-term depression in the prefrontal
cortex. Neuropharmacology. Elsevier. https://doi.org/10.1016/j.neuropharm.2010.05.013
chicago: Guzmán, José, Hartmut Schmidt, Heike Franke, Ute Krügel, Jens Eilers, Peter
Illes, and Zoltan Gerevich. “P2Y1 Receptors Inhibit Long-Term Depression in the
Prefrontal Cortex.” Neuropharmacology. Elsevier, 2010. https://doi.org/10.1016/j.neuropharm.2010.05.013.
ieee: J. Guzmán et al., “P2Y1 receptors inhibit long-term depression in the
prefrontal cortex.,” Neuropharmacology, vol. 59, no. 6. Elsevier, pp. 406–415,
2010.
ista: Guzmán J, Schmidt H, Franke H, Krügel U, Eilers J, Illes P, Gerevich Z. 2010.
P2Y1 receptors inhibit long-term depression in the prefrontal cortex. Neuropharmacology.
59(6), 406–415.
mla: Guzmán, José, et al. “P2Y1 Receptors Inhibit Long-Term Depression in the Prefrontal
Cortex.” Neuropharmacology, vol. 59, no. 6, Elsevier, 2010, pp. 406–15,
doi:10.1016/j.neuropharm.2010.05.013.
short: J. Guzmán, H. Schmidt, H. Franke, U. Krügel, J. Eilers, P. Illes, Z. Gerevich,
Neuropharmacology 59 (2010) 406–415.
date_created: 2018-12-11T12:04:47Z
date_published: 2010-11-01T00:00:00Z
date_updated: 2021-01-12T07:51:42Z
day: '01'
department:
- _id: PeJo
doi: 10.1016/j.neuropharm.2010.05.013
intvolume: ' 59'
issue: '6'
language:
- iso: eng
month: '11'
oa_version: None
page: 406 - 415
publication: Neuropharmacology
publication_status: published
publisher: Elsevier
publist_id: '2512'
quality_controlled: '1'
scopus_import: 1
status: public
title: P2Y1 receptors inhibit long-term depression in the prefrontal cortex.
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 59
year: '2010'
...