--- _id: '3662' abstract: - lang: eng text: The evolution of the probabilities of genetic identity within and between tandemly repeated loci of a multigene family is investigated analytically and numerically. Unbiased intrachromosomal gene conversion, equal crossing over, random genetic drift, and mutation to new alleles are incorporated. Generations are discrete and nonoverlapping; the diploid, monoecious population mates at random. Under the restriction that there is at most one crossover in the multigene family per individual per generation, the dependence on location of the probabilities of identity is treated exactly. In the “homogeneous” approximation to this “exact” model, end effects are disregarded; in the “exchangeable” approximation, to which all previous work was confined, all position dependence is neglected. Numerical results indicate that (i) the exchangeable and homogeneous models are both qualitatively correct, (ii) the exchangeable model is sometimes too inaccurate for quantitative conclusions, and (iii) the homogeneous model is always more accurate than the exchangeable one and is always sufficiently accurate for quantitative conclusions. acknowledgement: Supported by National Science Foundation Grant DEB81-03530 article_processing_charge: No article_type: original author: - first_name: Thomas full_name: Nagylaki, Thomas last_name: Nagylaki - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Nagylaki T, Barton NH. Intrachromosomal gene conversion, linkage, and the evolution of multigene families. Theoretical Population Biology. 1986;29(3):407-437. doi:10.1016/0040-5809(86)90017-1 apa: Nagylaki, T., & Barton, N. H. (1986). Intrachromosomal gene conversion, linkage, and the evolution of multigene families. Theoretical Population Biology. Academic Press. https://doi.org/10.1016/0040-5809(86)90017-1 chicago: Nagylaki, Thomas, and Nicholas H Barton. “Intrachromosomal Gene Conversion, Linkage, and the Evolution of Multigene Families.” Theoretical Population Biology. Academic Press, 1986. https://doi.org/10.1016/0040-5809(86)90017-1. ieee: T. Nagylaki and N. H. Barton, “Intrachromosomal gene conversion, linkage, and the evolution of multigene families,” Theoretical Population Biology, vol. 29, no. 3. Academic Press, pp. 407–437, 1986. ista: Nagylaki T, Barton NH. 1986. Intrachromosomal gene conversion, linkage, and the evolution of multigene families. Theoretical Population Biology. 29(3), 407–437. mla: Nagylaki, Thomas, and Nicholas H. Barton. “Intrachromosomal Gene Conversion, Linkage, and the Evolution of Multigene Families.” Theoretical Population Biology, vol. 29, no. 3, Academic Press, 1986, pp. 407–37, doi:10.1016/0040-5809(86)90017-1. short: T. Nagylaki, N.H. Barton, Theoretical Population Biology 29 (1986) 407–437. date_created: 2018-12-11T12:04:30Z date_published: 1986-06-01T00:00:00Z date_updated: 2022-02-01T15:50:10Z day: '01' doi: 10.1016/0040-5809(86)90017-1 extern: '1' intvolume: ' 29' issue: '3' language: - iso: eng month: '06' oa_version: None page: 407 - 437 publication: Theoretical Population Biology publication_identifier: eissn: - 1096-0325 issn: - 0040-5809 publication_status: published publisher: Academic Press publist_id: '2721' quality_controlled: '1' scopus_import: '1' status: public title: Intrachromosomal gene conversion, linkage, and the evolution of multigene families type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 29 year: '1986' ...