---
_id: '3662'
abstract:
- lang: eng
text: The evolution of the probabilities of genetic identity within and between
tandemly repeated loci of a multigene family is investigated analytically and
numerically. Unbiased intrachromosomal gene conversion, equal crossing over, random
genetic drift, and mutation to new alleles are incorporated. Generations are discrete
and nonoverlapping; the diploid, monoecious population mates at random. Under
the restriction that there is at most one crossover in the multigene family per
individual per generation, the dependence on location of the probabilities of
identity is treated exactly. In the “homogeneous” approximation to this “exact”
model, end effects are disregarded; in the “exchangeable” approximation, to which
all previous work was confined, all position dependence is neglected. Numerical
results indicate that (i) the exchangeable and homogeneous models are both qualitatively
correct, (ii) the exchangeable model is sometimes too inaccurate for quantitative
conclusions, and (iii) the homogeneous model is always more accurate than the
exchangeable one and is always sufficiently accurate for quantitative conclusions.
acknowledgement: Supported by National Science Foundation Grant DEB81-03530
article_processing_charge: No
article_type: original
author:
- first_name: Thomas
full_name: Nagylaki, Thomas
last_name: Nagylaki
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Nagylaki T, Barton NH. Intrachromosomal gene conversion, linkage, and the evolution
of multigene families. Theoretical Population Biology. 1986;29(3):407-437.
doi:10.1016/0040-5809(86)90017-1
apa: Nagylaki, T., & Barton, N. H. (1986). Intrachromosomal gene conversion,
linkage, and the evolution of multigene families. Theoretical Population Biology.
Academic Press. https://doi.org/10.1016/0040-5809(86)90017-1
chicago: Nagylaki, Thomas, and Nicholas H Barton. “Intrachromosomal Gene Conversion,
Linkage, and the Evolution of Multigene Families.” Theoretical Population Biology.
Academic Press, 1986. https://doi.org/10.1016/0040-5809(86)90017-1.
ieee: T. Nagylaki and N. H. Barton, “Intrachromosomal gene conversion, linkage,
and the evolution of multigene families,” Theoretical Population Biology,
vol. 29, no. 3. Academic Press, pp. 407–437, 1986.
ista: Nagylaki T, Barton NH. 1986. Intrachromosomal gene conversion, linkage, and
the evolution of multigene families. Theoretical Population Biology. 29(3), 407–437.
mla: Nagylaki, Thomas, and Nicholas H. Barton. “Intrachromosomal Gene Conversion,
Linkage, and the Evolution of Multigene Families.” Theoretical Population Biology,
vol. 29, no. 3, Academic Press, 1986, pp. 407–37, doi:10.1016/0040-5809(86)90017-1.
short: T. Nagylaki, N.H. Barton, Theoretical Population Biology 29 (1986) 407–437.
date_created: 2018-12-11T12:04:30Z
date_published: 1986-06-01T00:00:00Z
date_updated: 2022-02-01T15:50:10Z
day: '01'
doi: 10.1016/0040-5809(86)90017-1
extern: '1'
intvolume: ' 29'
issue: '3'
language:
- iso: eng
month: '06'
oa_version: None
page: 407 - 437
publication: Theoretical Population Biology
publication_identifier:
eissn:
- 1096-0325
issn:
- 0040-5809
publication_status: published
publisher: Academic Press
publist_id: '2721'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Intrachromosomal gene conversion, linkage, and the evolution of multigene families
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 29
year: '1986'
...