---
_id: '3652'
abstract:
- lang: eng
text: Frequency-dependent selection against rare forms can maintain clines. For
weak selection, s, in simple linear models of frequency-dependence, single locus
clines are stabilized with a maximum slope of between square root of s/square
root of 8 sigma and square root of s/square root of 12 delta, where sigma is the
dispersal distance. These clines are similar to those maintained by heterozygote
disadvantage. Using computer simulations, the weak-selection analytical results
are extended to higher selection pressures with up to three unlinked genes. Graphs
are used to display the effect of selection, migration, dominance, and number
of loci on cline widths, speeds of cline movements, two-way gametic correlations
("linkage disequilibria"), and heterozygote deficits. The effects of changing
the order of reproduction, migration, and selection, are also briefly explored.
Epistasis can also maintain tension zones. We show that epistatic selection is
similar in its effects to frequency-dependent selection, except that the disequilibria
produced in the zone will be higher for a given level of selection. If selection
consists of a mixture of frequency-dependence and epistasis, as is likely in nature,
the error made in estimating selection is usually less than twofold. From the
graphs, selection and migration can be estimated using knowledge of the dominance
and number of genes, of gene frequencies and of gametic correlations from a hybrid
zone.
acknowledgement: "The publication costs of this article were partly defrayed by the
payment of page charges. This article must therefore be hereby marked “advertisment”
in accordance with 18 U.S.C. §1734 solely to indicate this fact. \r\n\r\nWe thank
the Natural Environmental Research Council for financial support, and N. SANDERSON,
M. SLATKIN and an anonymous reviewer for comments on the manuscript."
article_processing_charge: No
article_type: original
author:
- first_name: James
full_name: Mallet, James
last_name: Mallet
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Mallet J, Barton NH. Inference from clines stabilized by frequency-dependent
selection. Genetics. 1989;122(4):967-976. doi:10.1093/genetics/122.4.967
apa: Mallet, J., & Barton, N. H. (1989). Inference from clines stabilized by
frequency-dependent selection. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/122.4.967
chicago: Mallet, James, and Nicholas H Barton. “Inference from Clines Stabilized
by Frequency-Dependent Selection.” Genetics. Genetics Society of America,
1989. https://doi.org/10.1093/genetics/122.4.967.
ieee: J. Mallet and N. H. Barton, “Inference from clines stabilized by frequency-dependent
selection,” Genetics, vol. 122, no. 4. Genetics Society of America, pp.
967–976, 1989.
ista: Mallet J, Barton NH. 1989. Inference from clines stabilized by frequency-dependent
selection. Genetics. 122(4), 967–976.
mla: Mallet, James, and Nicholas H. Barton. “Inference from Clines Stabilized by
Frequency-Dependent Selection.” Genetics, vol. 122, no. 4, Genetics Society
of America, 1989, pp. 967–76, doi:10.1093/genetics/122.4.967.
short: J. Mallet, N.H. Barton, Genetics 122 (1989) 967–976.
date_created: 2018-12-11T12:04:27Z
date_published: 1989-08-01T00:00:00Z
date_updated: 2022-02-14T14:07:12Z
day: '01'
doi: 10.1093/genetics/122.4.967
extern: '1'
external_id:
pmid:
- '2759433'
intvolume: ' 122'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1203771
month: '08'
oa: 1
oa_version: None
page: 967 - 976
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2731'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Inference from clines stabilized by frequency-dependent selection
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 122
year: '1989'
...