---
res:
bibo_abstract:
- Selection on polygenic characters is generally analyzed by statistical methods
that assume a Gaussian (normal) distribution of breeding values. We present an
alternative analysis based on multilocus population genetics. We use a general
representation of selection, recombination, and drift to analyze an idealized
polygenic system in which all genetic effects are additive (i.e., both dominance
and epistasis are absent), but no assumptions are made about the distribution
of breeding values or the numbers of loci or alleles. Our analysis produces three
results. First, our equations reproduce the standard recursions for the mean and
additive variance if breeding values are Gaussian; but they also reveal how non-Gaussian
distributions of breeding values will alter these dynamics. Second, an approximation
valid for weak selection shows that even if genetic variance is attributable to
an effectively infinite number of loci with only additive effects, selection will
generally drive the distribution of breeding values away from a Gaussian distribution
by creating multilocus linkage disequilibria. Long-term dynamics of means can
depart substantially from the predictions of the standard selection recursions,
but the discrepancy may often be negligible for short-term selection. Third, by
including mutation, we show that, for realistic parameter values, linkage disequilibrium
has little effect on the amount of additive variance maintained at an equilibrium
between stabilizing selection and mutation. Each of these analytical results is
supported by numerical calculations.@eng
bibo_authorlist:
- foaf_Person:
foaf_givenName: Michael
foaf_name: Turelli, Michael
foaf_surname: Turelli
- foaf_Person:
foaf_givenName: Nicholas H
foaf_name: Nicholas Barton
foaf_surname: Barton
foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
orcid: 0000-0002-8548-5240
bibo_doi: 10.1016/0040-5809(90)90002-D
bibo_issue: '1'
bibo_volume: 38
dct_date: 1990^xs_gYear
dct_publisher: Academic Press@
dct_title: Dynamics of polygenic characters under selection@
...