--- _id: '3641' abstract: - lang: eng text: The probability of fixation of a mutation with selective advantage s will be reduced by substitutions at other loci. The effect of a single substitution, with selective advantage S0016672300032857inline1, can be approximated as a sudden reduction in the frequency of the favourable allele, by a fraction w = 1 −(s/S)r/s (where r is the recombination rate). An expression for the effect of a given sequence of such catastrophes is derived. This also applies to the ecological prxoblem of finding the probability that a small population will survive, despite occasional disasters. It is shown that if substitutions occur at a rate Δ, and are scattered randomly over a genetic map of length R, then an allele is unlikely to be fixed if its advantage is less than a critical value, Scrit = (π2/6)(2ΔS/(Rlog(S/s))). This threshold depends primarily on the variance in fitness per unit map length dueto substitutions, var(W)/R = 2ΔS/R. With no recombination, the fixation probability can be calculated for a finite population. If Δ > s, it is of the same order as for a neutral allele ( ≈ Δ/(2N(Δ−s))), whilst if S0016672300032857inline2, fixation probability is much higher than for a neutral allele, but much lower than in the absence of hitch-hiking S0016672300032857inline3. These results suggest that hitch-hiking may substantially impede the accumulation of weakly favoured adaptations. article_processing_charge: No article_type: original author: - first_name: Nicholas H full_name: Barton, Nicholas H id: 4880FE40-F248-11E8-B48F-1D18A9856A87 last_name: Barton orcid: 0000-0002-8548-5240 citation: ama: Barton NH. The reduction in fixation probability caused by substitutions at linked loci. Genetical Research. 1994;64(3):199-208. doi:10.1017/S0016672300032857 apa: Barton, N. H. (1994). The reduction in fixation probability caused by substitutions at linked loci. Genetical Research. Cambridge University Press. https://doi.org/10.1017/S0016672300032857 chicago: Barton, Nicholas H. “The Reduction in Fixation Probability Caused by Substitutions at Linked Loci.” Genetical Research. Cambridge University Press, 1994. https://doi.org/10.1017/S0016672300032857 . ieee: N. H. Barton, “The reduction in fixation probability caused by substitutions at linked loci,” Genetical Research, vol. 64, no. 3. Cambridge University Press, pp. 199–208, 1994. ista: Barton NH. 1994. The reduction in fixation probability caused by substitutions at linked loci. Genetical Research. 64(3), 199–208. mla: Barton, Nicholas H. “The Reduction in Fixation Probability Caused by Substitutions at Linked Loci.” Genetical Research, vol. 64, no. 3, Cambridge University Press, 1994, pp. 199–208, doi:10.1017/S0016672300032857 . short: N.H. Barton, Genetical Research 64 (1994) 199–208. date_created: 2018-12-11T12:04:23Z date_published: 1994-12-01T00:00:00Z date_updated: 2022-06-03T08:34:32Z day: '01' doi: '10.1017/S0016672300032857 ' extern: '1' intvolume: ' 64' issue: '3' language: - iso: eng main_file_link: - url: https://www.cambridge.org/core/journals/genetics-research/article/reduction-in-fixation-probability-caused-by-substitutions-at-linked-loci/458BBF3E7FE92E4EA6AFB2B000A98945 month: '12' oa_version: None page: 199 - 208 publication: Genetical Research publication_identifier: issn: - 0016-6723 publication_status: published publisher: Cambridge University Press publist_id: '2742' quality_controlled: '1' scopus_import: '1' status: public title: The reduction in fixation probability caused by substitutions at linked loci type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 64 year: '1994' ...