{"month":"12","_id":"3641","date_created":"2018-12-11T12:04:23Z","publist_id":"2742","day":"01","volume":64,"publication":"Genetical Research","issue":"3","doi":"10.1017/S0016672300032857 ","title":"The reduction in fixation probability caused by substitutions at linked loci","intvolume":" 64","date_updated":"2021-01-12T07:44:51Z","extern":1,"publication_status":"published","year":"1994","quality_controlled":0,"page":"199 - 208","date_published":"1994-12-01T00:00:00Z","abstract":[{"text":"The probability of fixation of a mutation with selective advantage s will be reduced by substitutions at other loci. The effect of a single substitution, with selective advantage S0016672300032857inline1, can be approximated as a sudden reduction in the frequency of the favourable allele, by a fraction w = 1 −(s/S)r/s (where r is the recombination rate). An expression for the effect of a given sequence of such catastrophes is derived. This also applies to the ecological prxoblem of finding the probability that a small population will survive, despite occasional disasters. It is shown that if substitutions occur at a rate Δ, and are scattered randomly over a genetic map of length R, then an allele is unlikely to be fixed if its advantage is less than a critical value, Scrit = (π2/6)(2ΔS/(Rlog(S/s))). This threshold depends primarily on the variance in fitness per unit map length dueto substitutions, var(W)/R = 2ΔS/R. With no recombination, the fixation probability can be calculated for a finite population. If Δ > s, it is of the same order as for a neutral allele ( ≈ Δ/(2N(Δ−s))), whilst if S0016672300032857inline2, fixation probability is much higher than for a neutral allele, but much lower than in the absence of hitch-hiking S0016672300032857inline3. These results suggest that hitch-hiking may substantially impede the accumulation of weakly favoured adaptations.","lang":"eng"}],"type":"journal_article","author":[{"first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Nicholas Barton"}],"status":"public","publisher":"Cambridge University Press","citation":{"mla":"Barton, Nicholas H. “The Reduction in Fixation Probability Caused by Substitutions at Linked Loci.” *Genetical Research*, vol. 64, no. 3, Cambridge University Press, 1994, pp. 199–208, doi:10.1017/S0016672300032857 .","short":"N.H. Barton, Genetical Research 64 (1994) 199–208.","apa":"Barton, N. H. (1994). The reduction in fixation probability caused by substitutions at linked loci. *Genetical Research*. Cambridge University Press. https://doi.org/10.1017/S0016672300032857 ","chicago":"Barton, Nicholas H. “The Reduction in Fixation Probability Caused by Substitutions at Linked Loci.” *Genetical Research*. Cambridge University Press, 1994. https://doi.org/10.1017/S0016672300032857 .","ista":"Barton NH. 1994. The reduction in fixation probability caused by substitutions at linked loci. Genetical Research. 64(3), 199–208.","ieee":"N. H. Barton, “The reduction in fixation probability caused by substitutions at linked loci,” *Genetical Research*, vol. 64, no. 3. Cambridge University Press, pp. 199–208, 1994.","ama":"Barton NH. The reduction in fixation probability caused by substitutions at linked loci. *Genetical Research*. 1994;64(3):199-208. doi:10.1017/S0016672300032857 "}}