---
res:
bibo_abstract:
- The probability of fixation of a mutation with selective advantage s will be reduced
by substitutions at other loci. The effect of a single substitution, with selective
advantage S0016672300032857inline1, can be approximated as a sudden reduction
in the frequency of the favourable allele, by a fraction w = 1 −(s/S)r/s (where
r is the recombination rate). An expression for the effect of a given sequence
of such catastrophes is derived. This also applies to the ecological prxoblem
of finding the probability that a small population will survive, despite occasional
disasters. It is shown that if substitutions occur at a rate Δ, and are scattered
randomly over a genetic map of length R, then an allele is unlikely to be fixed
if its advantage is less than a critical value, Scrit = (π2/6)(2ΔS/(Rlog(S/s))).
This threshold depends primarily on the variance in fitness per unit map length
dueto substitutions, var(W)/R = 2ΔS/R. With no recombination, the fixation probability
can be calculated for a finite population. If Δ > s, it is of the same order
as for a neutral allele ( ≈ Δ/(2N(Δ−s))), whilst if S0016672300032857inline2,
fixation probability is much higher than for a neutral allele, but much lower
than in the absence of hitch-hiking S0016672300032857inline3. These results suggest
that hitch-hiking may substantially impede the accumulation of weakly favoured
adaptations.@eng
bibo_authorlist:
- foaf_Person:
foaf_givenName: Nicholas H
foaf_name: Nicholas Barton
foaf_surname: Barton
foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
orcid: 0000-0002-8548-5240
bibo_doi: '10.1017/S0016672300032857 '
bibo_issue: '3'
bibo_volume: 64
dct_date: 1994^xs_gYear
dct_publisher: Cambridge University Press@
dct_title: The reduction in fixation probability caused by substitutions at linked
loci@
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