---
_id: '3538'
abstract:
- lang: eng
text: How seizures start is a major question in epilepsy research. Preictal EEG
changes occur in both human patients and animal models, but their underlying mechanisms
and relationship with seizure initiation remain unknown. Here we demonstrate the
existence, in the hippocampal CA1 region, of a preictal state characterized by
the progressive and global increase in neuronal activity associated with a widespread
buildup of low-amplitude high-frequency activity (HFA) (> 100 Hz) and reduction
in system complexity. HFA is generated by the firing of neurons, mainly pyramidal
cells, at much lower frequencies. Individual cycles of HFA are generated by the
near-synchronous (within similar to 5 ms) firing of small numbers of pyramidal
cells. The presence of HFA in the low-calcium model implicates nonsynaptic synchronization;
the presence of very similar HFA in the high-potassium model shows that it does
not depend on an absence of synaptic transmission. Immediately before seizure
onset, CA1 is in a state of high sensitivity in which weak depolarizing or synchronizing
perturbations can trigger seizures. Transition to seizure is characterized by
a rapid expansion and fusion of the neuronal populations responsible for HFA,
associated with a progressive slowing of HFA, leading to a single, massive, hypersynchronous
cluster generating the high-amplitude low-frequency activity of the seizure.
author:
- first_name: Premysl
full_name: Jiruska, Premysl
last_name: Jiruska
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Andrew
full_name: Powell, Andrew
last_name: Powell
- first_name: John
full_name: Fox, John
last_name: Fox
- first_name: Wei
full_name: Chang, Wei
last_name: Chang
- first_name: Martin
full_name: Vreugdenhil, Martin
last_name: Vreugdenhil
- first_name: Xiaoli
full_name: Li, Xiaoli
last_name: Li
- first_name: Milan
full_name: Palus, Milan
last_name: Palus
- first_name: Alejandro
full_name: Bujan, Alejandro
last_name: Bujan
- first_name: Richard
full_name: Dearden, Richard
last_name: Dearden
- first_name: John
full_name: Jefferys, John
last_name: Jefferys
citation:
ama: Jiruska P, Csicsvari JL, Powell A, et al. High-frequency network activity,
global increase in neuronal activity, and synchrony expansion precede epileptic
seizures in vitro. Journal of Neuroscience. 2010;30(16):5690-5701. doi:10.1523/JNEUROSCI.0535-10.2010
apa: Jiruska, P., Csicsvari, J. L., Powell, A., Fox, J., Chang, W., Vreugdenhil,
M., … Jefferys, J. (2010). High-frequency network activity, global increase in
neuronal activity, and synchrony expansion precede epileptic seizures in vitro.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.0535-10.2010
chicago: Jiruska, Premysl, Jozsef L Csicsvari, Andrew Powell, John Fox, Wei Chang,
Martin Vreugdenhil, Xiaoli Li, et al. “High-Frequency Network Activity, Global
Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures
in Vitro.” Journal of Neuroscience. Society for Neuroscience, 2010. https://doi.org/10.1523/JNEUROSCI.0535-10.2010.
ieee: P. Jiruska et al., “High-frequency network activity, global increase
in neuronal activity, and synchrony expansion precede epileptic seizures in vitro,”
Journal of Neuroscience, vol. 30, no. 16. Society for Neuroscience, pp.
5690–5701, 2010.
ista: Jiruska P, Csicsvari JL, Powell A, Fox J, Chang W, Vreugdenhil M, Li X, Palus
M, Bujan A, Dearden R, Jefferys J. 2010. High-frequency network activity, global
increase in neuronal activity, and synchrony expansion precede epileptic seizures
in vitro. Journal of Neuroscience. 30(16), 5690–5701.
mla: Jiruska, Premysl, et al. “High-Frequency Network Activity, Global Increase
in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro.”
Journal of Neuroscience, vol. 30, no. 16, Society for Neuroscience, 2010,
pp. 5690–701, doi:10.1523/JNEUROSCI.0535-10.2010.
short: P. Jiruska, J.L. Csicsvari, A. Powell, J. Fox, W. Chang, M. Vreugdenhil,
X. Li, M. Palus, A. Bujan, R. Dearden, J. Jefferys, Journal of Neuroscience 30
(2010) 5690–5701.
date_created: 2018-12-11T12:03:51Z
date_published: 2010-04-21T00:00:00Z
date_updated: 2021-01-12T07:44:10Z
day: '21'
doi: 10.1523/JNEUROSCI.0535-10.2010
extern: '1'
intvolume: ' 30'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.jneurosci.org/content/30/16/5690
month: '04'
oa: 1
oa_version: None
page: 5690 - 5701
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '2848'
quality_controlled: '1'
status: public
title: High-frequency network activity, global increase in neuronal activity, and
synchrony expansion precede epileptic seizures in vitro
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 30
year: '2010'
...