---
_id: '3537'
abstract:
- lang: eng
text: 'Hippocampal place cells that fire together within the same cycle of theta
oscillations represent the sequence of positions (movement trajectory) that a
rat traverses on a linear track. Furthermore, it has been suggested that the encoding
of these and other types of temporal memory sequences is organized by gamma oscillations
nested within theta oscillations. Here, we examined whether gamma-related firing
of place cells permits such discrete temporal coding. We found that gamma-modulated
CA1 pyramidal cells separated into two classes on the basis of gamma firing phases
during waking theta periods. These groups also differed in terms of their spike
waveforms, firing rates, and burst firing tendency. During gamma oscillations
one group''s firing became restricted to theta phases associated with the highest
gamma power. Consequently, on the linear track, cells in this group often failed
to fire early in theta-phase precession (as the rat entered the place field) if
gamma oscillations were present. The second group fired throughout the theta cycle
during gamma oscillations, and maintained gamma-modulated firing at different
stages of theta-phase precession. Our results suggest that the two different pyramidal
cell classes may support different types of population codes within a theta cycle:
one in which spike sequences representing movement trajectories occur across subsequent
gamma cycles nested within each theta cycle, and another in which firing in synchronized
gamma discharges without temporal sequences encode a representation of location.
We propose that gamma oscillations during theta-phase precession organize the
mnemonic recall of population patterns representing places and movement paths.'
author:
- first_name: Timothy
full_name: Senior,Timothy J
last_name: Senior
- first_name: John
full_name: Huxter,John R
last_name: Huxter
- first_name: Kevin
full_name: Allen, Kevin
last_name: Allen
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Senior T, Huxter J, Allen K, O’Neill J, Csicsvari JL. Gamma oscillatory firing
reveals distinct populations of pyramidal cells in the CA1 region of the hippocampus.
Journal of Neuroscience. 2008;28(9):2274-2286. doi:10.1523/JNEUROSCI.4669-07.2008
apa: Senior, T., Huxter, J., Allen, K., O’Neill, J., & Csicsvari, J. L. (2008).
Gamma oscillatory firing reveals distinct populations of pyramidal cells in the
CA1 region of the hippocampus. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.4669-07.2008
chicago: Senior, Timothy, John Huxter, Kevin Allen, Joseph O’Neill, and Jozsef L
Csicsvari. “Gamma Oscillatory Firing Reveals Distinct Populations of Pyramidal
Cells in the CA1 Region of the Hippocampus.” Journal of Neuroscience. Society
for Neuroscience, 2008. https://doi.org/10.1523/JNEUROSCI.4669-07.2008.
ieee: T. Senior, J. Huxter, K. Allen, J. O’Neill, and J. L. Csicsvari, “Gamma oscillatory
firing reveals distinct populations of pyramidal cells in the CA1 region of the
hippocampus,” Journal of Neuroscience, vol. 28, no. 9. Society for Neuroscience,
pp. 2274–2286, 2008.
ista: Senior T, Huxter J, Allen K, O’Neill J, Csicsvari JL. 2008. Gamma oscillatory
firing reveals distinct populations of pyramidal cells in the CA1 region of the
hippocampus. Journal of Neuroscience. 28(9), 2274–2286.
mla: Senior, Timothy, et al. “Gamma Oscillatory Firing Reveals Distinct Populations
of Pyramidal Cells in the CA1 Region of the Hippocampus.” Journal of Neuroscience,
vol. 28, no. 9, Society for Neuroscience, 2008, pp. 2274–86, doi:10.1523/JNEUROSCI.4669-07.2008.
short: T. Senior, J. Huxter, K. Allen, J. O’Neill, J.L. Csicsvari, Journal of Neuroscience
28 (2008) 2274–2286.
date_created: 2018-12-11T12:03:51Z
date_published: 2008-02-27T00:00:00Z
date_updated: 2021-01-12T07:44:09Z
day: '27'
doi: 10.1523/JNEUROSCI.4669-07.2008
extern: 1
intvolume: ' 28'
issue: '9'
month: '02'
page: 2274 - 2286
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '2847'
quality_controlled: 0
status: public
title: Gamma oscillatory firing reveals distinct populations of pyramidal cells in
the CA1 region of the hippocampus
type: journal_article
volume: 28
year: '2008'
...