Reactivation of experience-dependent cell assembly patterns in the hippocampus

J. O’Neill, T. Senior, K. Allen, J. Huxter, J.L. Csicsvari, Nature Neuroscience 11 (2008) 209–215.

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Abstract
The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places increased relative to the sleep session before exploration. This cofiring increase depended on the number of times that cells fired together with short latencies ( < 50 ms) during exploration, and was strongest between cells representing the most visited places. This is indicative of a Hebbian learning rule in which changes in firing associations between cells are determined by the number of waking coincident firing events. In contrast, cells encoding different locations reduced their cofiring in proportion to the number of times that they fired independently. Together these data indicate that reactivated patterns are shaped by both positive and negative changes in cofiring, which are determined by recent behavior.
Publishing Year
Date Published
2008-02-01
Journal Title
Nature Neuroscience
Volume
11
Issue
2
Page
209 - 215
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O’Neill J, Senior T, Allen K, Huxter J, Csicsvari JL. Reactivation of experience-dependent cell assembly patterns in the hippocampus. Nature Neuroscience. 2008;11(2):209-215. doi:10.1038/nn2037
O’Neill, J., Senior, T., Allen, K., Huxter, J., & Csicsvari, J. L. (2008). Reactivation of experience-dependent cell assembly patterns in the hippocampus. Nature Neuroscience, 11(2), 209–215. https://doi.org/10.1038/nn2037
O’Neill, Joseph, Timothy Senior, Kevin Allen, John Huxter, and Jozsef L Csicsvari. “Reactivation of Experience-Dependent Cell Assembly Patterns in the Hippocampus.” Nature Neuroscience 11, no. 2 (2008): 209–15. https://doi.org/10.1038/nn2037.
J. O’Neill, T. Senior, K. Allen, J. Huxter, and J. L. Csicsvari, “Reactivation of experience-dependent cell assembly patterns in the hippocampus,” Nature Neuroscience, vol. 11, no. 2, pp. 209–215, 2008.
O’Neill J, Senior T, Allen K, Huxter J, Csicsvari JL. 2008. Reactivation of experience-dependent cell assembly patterns in the hippocampus. Nature Neuroscience. 11(2), 209–215.
O’Neill, Joseph, et al. “Reactivation of Experience-Dependent Cell Assembly Patterns in the Hippocampus.” Nature Neuroscience, vol. 11, no. 2, Nature Publishing Group, 2008, pp. 209–15, doi:10.1038/nn2037.

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