Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons

J. Geiger, P.M. Jonas, Neuron 28 (2000) 927–939.

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Abstract
Analysis of presynaptic determinants of synaptic strength has been difficult at cortical synapses, mainly due to the lack of direct access to presynaptic elements. Here we report patch-clamp recordings from mossy fiber boutons (MFBs) in rat hippocampal slices. The presynaptic action potential is very short during low-frequency stimulation but is prolonged up to 3-fold during high-frequency stimulation. Voltage-gated K+ channels in MFBs inactivate rapidly but recover from inactivation very slowly, suggesting that cumulative K+ channel inactivation mediates activity-dependent spike broadening. Prolongation of the presynaptic voltage waveform leads to an increase in the number of Ca2+ ions entering the terminal per action potential and to a consecutive potentiation of evoked excitatory postsynaptic currents at MFB-CA3 pyramidal cell synapses. Thus, inactivation of presynaptic K+ channels contributes to the control of efficacy of a glutamatergic synapse in the cortex.
Publishing Year
Date Published
2000-12-01
Journal Title
Neuron
Volume
28
Issue
3
Page
927 - 939
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Geiger J, Jonas PM. Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron. 2000;28(3):927-939. doi:10.1016/S0896-6273(00)00164-1
Geiger, J., & Jonas, P. M. (2000). Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron, 28(3), 927–939. https://doi.org/10.1016/S0896-6273(00)00164-1
Geiger, Jörg, and Peter M Jonas. “Dynamic Control of Presynaptic Ca(2+) Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron 28, no. 3 (2000): 927–39. https://doi.org/10.1016/S0896-6273(00)00164-1.
J. Geiger and P. M. Jonas, “Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons,” Neuron, vol. 28, no. 3, pp. 927–939, 2000.
Geiger J, Jonas PM. 2000. Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron. 28(3), 927–939.
Geiger, Jörg, and Peter M. Jonas. “Dynamic Control of Presynaptic Ca(2+) Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron, vol. 28, no. 3, Elsevier, 2000, pp. 927–39, doi:10.1016/S0896-6273(00)00164-1.

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