Distal initiation and active propagation of action potentials in interneuron dendrites

M. Martina, I. Vida, P.M. Jonas, Science 287 (2000) 295–300.

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Abstract
Fast and reliable activation of inhibitory interneurons is critical for the stability of cortical neuronal networks. Active conductances in dendrites may facilitate interneuron activation, but direct experimental evidence was unavailable. Patch-clamp recordings from dendrites of hippocampal oriens- alveus interneurons revealed high densities of voltage-gated sodium and potassium ion channels. Simultaneous recordings from dendrites and somata suggested that action potential initiation occurs preferentially in the axon with long threshold stimuli, but can be shifted to somatodendritic sites when brief stimuli are applied. After initiation, action potentials propagate over the somatodendritic domain with constant amplitude, high velocity, and reliability, even during high-frequency trains.
Publishing Year
Date Published
2000-01-14
Journal Title
Science
Volume
287
Issue
5451
Page
295 - 300
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Martina M, Vida I, Jonas PM. Distal initiation and active propagation of action potentials in interneuron dendrites. Science. 2000;287(5451):295-300. doi:10.1126/science.287.5451.295
Martina, M., Vida, I., & Jonas, P. M. (2000). Distal initiation and active propagation of action potentials in interneuron dendrites. Science, 287(5451), 295–300. https://doi.org/10.1126/science.287.5451.295
Martina, Marco, Imre Vida, and Peter M Jonas. “Distal Initiation and Active Propagation of Action Potentials in Interneuron Dendrites.” Science 287, no. 5451 (2000): 295–300. https://doi.org/10.1126/science.287.5451.295.
M. Martina, I. Vida, and P. M. Jonas, “Distal initiation and active propagation of action potentials in interneuron dendrites,” Science, vol. 287, no. 5451, pp. 295–300, 2000.
Martina M, Vida I, Jonas PM. 2000. Distal initiation and active propagation of action potentials in interneuron dendrites. Science. 287(5451), 295–300.
Martina, Marco, et al. “Distal Initiation and Active Propagation of Action Potentials in Interneuron Dendrites.” Science, vol. 287, no. 5451, American Association for the Advancement of Science, 2000, pp. 295–300, doi:10.1126/science.287.5451.295.

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