{"abstract":[{"lang":"eng","text":"Glutamate-operated ion channels (GluR channels) of the L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-kainate subtype are found in both neurons and glial cells of the central nervous system. These channels are assembled from the GluR-A, -B, -C, and -D subunits; channels containing a GluR-B subunit show an outwardly rectifying current-voltage relation and low calcium permeability, whereas channels lacking the GluR-B subunit are characterized by a doubly rectifying current-voltage relation and high calcium permeability. Most cell types in the central nervous system coexpress several subunits, including GluR-B. However, Bergmann glia in rat cerebellum do not express GluR-B subunit genes. In a subset of cultured cerebellar glial cells, likely derived from Bergmann glial cells. GluR channels exhibit doubly rectifying current-voltage relations and high calcium permeability, whereas GluR channels of cerebellar neurons have low calcium permeability. Thus, differential expression of the GluR-B subunit gene in neurons and glia is one mechanism by which functional properties of native GluR channels are regulated."}],"type":"journal_article","publication_identifier":{"issn":["0036-8075"]},"status":"public","article_type":"original","quality_controlled":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","citation":{"mla":"Burnashev, Nail, et al. “Calcium-Permeable AMPA-Kainate Receptors in Fusiform Cerebellar Glial Cells.” Science, vol. 256, no. 5063, American Association for the Advancement of Science, 1992, pp. 1566–70, doi:10.1126/science.1317970.","ista":"Burnashev N, Khodorova A, Jonas PM, Helm P, Wisden W, Monyer H, Seeburg P, Sakmann B. 1992. Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells. Science. 256(5063), 1566–1570.","ieee":"N. Burnashev et al., “Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells.,” Science, vol. 256, no. 5063. American Association for the Advancement of Science, pp. 1566–1570, 1992.","short":"N. Burnashev, A. Khodorova, P.M. Jonas, P. Helm, W. Wisden, H. Monyer, P. Seeburg, B. Sakmann, Science 256 (1992) 1566–1570.","ama":"Burnashev N, Khodorova A, Jonas PM, et al. Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells. Science. 1992;256(5063):1566-1570. doi:10.1126/science.1317970","apa":"Burnashev, N., Khodorova, A., Jonas, P. M., Helm, P., Wisden, W., Monyer, H., … Sakmann, B. (1992). Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1317970","chicago":"Burnashev, Nail, Alla Khodorova, Peter M Jonas, P. Helm, William Wisden, Hannah Monyer, Peter Seeburg, and Bert Sakmann. “Calcium-Permeable AMPA-Kainate Receptors in Fusiform Cerebellar Glial Cells.” Science. American Association for the Advancement of Science, 1992. https://doi.org/10.1126/science.1317970."},"language":[{"iso":"eng"}],"year":"1992","article_processing_charge":"No","title":"Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells.","_id":"3469","main_file_link":[{"url":"https://www.science.org/doi/10.1126/science.1317970"}],"oa_version":"None","author":[{"last_name":"Burnashev","full_name":"Burnashev, Nail","first_name":"Nail"},{"last_name":"Khodorova","first_name":"Alla","full_name":"Khodorova, Alla"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","last_name":"Jonas","full_name":"Jonas, Peter M","first_name":"Peter M"},{"full_name":"Helm, P.","first_name":"P.","last_name":"Helm"},{"last_name":"Wisden","first_name":"William","full_name":"Wisden, William"},{"last_name":"Monyer","first_name":"Hannah","full_name":"Monyer, Hannah"},{"first_name":"Peter","full_name":"Seeburg, Peter","last_name":"Seeburg"},{"last_name":"Sakmann","full_name":"Sakmann, Bert","first_name":"Bert"}],"publisher":"American Association for the Advancement of Science","external_id":{"pmid":["1317970"]},"issue":"5063","publication_status":"published","month":"06","date_updated":"2022-03-16T13:24:52Z","scopus_import":"1","doi":"10.1126/science.1317970","page":"1566 - 1570","day":"12","intvolume":" 256","publication":"Science","publist_id":"2918","pmid":1,"date_published":"1992-06-12T00:00:00Z","date_created":"2018-12-11T12:03:30Z","volume":256}