@article{3468, abstract = {Two types of metabolically regulated K channels have been identified for the first time in enzymatically demyelinated fibres of amphibian sciatic nerve using the patch-clamp technique. A maxi K channel with a single-channel conductance of 132 pS (105 mM K on both sides of the membrane, 15°C) is activated both by micromolar concentrations of internal Ca and by depolarization. A second type of K channel with a conductance of 44 pS is inhibited by intracellular adenosine 5'-triphosphate (ATP) with a half-maximal inhibitory concentration (IC50) of 35 μM. It is blocked by submicromolar concentrations of external glibenclamide. Both channels are sensitive to external tetraethylammonium chloride (IC50 = 0.2 mM for the maxi K channel and 4.2 mM for the ATP-sensitive channel). They may be part of a complex feedback system regulating axonal excitability under various metabolic conditions. }, author = {Jonas, Peter M and Koh, Duk and Kampe, Knut and Hermsteiner, Markus and Vogel, Werner}, issn = {1432-2013}, journal = {Pflügers Archiv : European Journal of Physiology}, number = {1-2}, pages = {68 -- 73}, publisher = {Springer}, title = {{ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability}}, doi = {10.1007/BF00370453}, volume = {418}, year = {1991}, }