--- res: bibo_abstract: - "Two types of metabolically regulated K channels have been identified for the first time in enzymatically demyelinated fibres of amphibian sciatic nerve using the patch-clamp technique. A maxi K channel with a single-channel conductance of 132 pS (105 mM K on both sides of the membrane, 15°C) is activated both by micromolar concentrations of internal Ca and by depolarization. A second type of K channel with a conductance of 44 pS is inhibited by intracellular adenosine 5'-triphosphate (ATP) with a half-maximal inhibitory concentration (IC50) of 35 μM. It is blocked by submicromolar concentrations of external glibenclamide. Both channels are sensitive to external tetraethylammonium chloride (IC50 = 0.2 mM for the maxi K channel and 4.2 mM for the ATP-sensitive channel). They may be part of a complex feedback system regulating axonal excitability under various metabolic conditions.\r\n@eng" bibo_authorlist: - foaf_Person: foaf_givenName: Peter M foaf_name: Jonas, Peter M foaf_surname: Jonas foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-5001-4804 - foaf_Person: foaf_givenName: Duk foaf_name: Koh, Duk foaf_surname: Koh - foaf_Person: foaf_givenName: Knut foaf_name: Kampe, Knut foaf_surname: Kampe - foaf_Person: foaf_givenName: Markus foaf_name: Hermsteiner, Markus foaf_surname: Hermsteiner - foaf_Person: foaf_givenName: Werner foaf_name: Vogel, Werner foaf_surname: Vogel bibo_doi: 10.1007/BF00370453 bibo_issue: 1-2 bibo_volume: 418 dct_date: 1991^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/0031-6768 - http://id.crossref.org/issn/1432-2013 dct_language: eng dct_publisher: Springer@ dct_title: 'ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability@' fabio_hasPubmedId: '2041727' ...