ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability

P.M. Jonas, D. Koh, K. Kampe, M. Hermsteiner, W. Vogel, Pflugers Archiv : European Journal of Physiology 418 (1991) 68–73.

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Abstract
Two types of metabolically regulated K channels have been identified for the first time in enzymatically demyelinated fibres of amphibian sciatic nerve using the patch-clamp technique. A maxi K channel with a single-channel conductance of 132 pS (105 mM K on both sides of the membrane, 15°C) is activated both by micromolar concentrations of internal Ca and by depolarization. A second type of K channel with a conductance of 44 pS is inhibited by intracellular adenosine 5'-triphosphate (ATP) with a half-maximal inhibitory concentration (IC50) of 35 μM. It is blocked by submicromolar concentrations of external glibenclamide. Both channels are sensitive to external tetraethylammonium chloride (IC50 = 0.2 mM for the maxi K channel and 4.2 mM for the ATP-sensitive channel). They may be part of a complex feedback system regulating axonal excitability under various metabolic conditions.
Publishing Year
Date Published
1991-01-01
Journal Title
Pflugers Archiv : European Journal of Physiology
Volume
418
Issue
1-2
Page
68 - 73
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Jonas PM, Koh D, Kampe K, Hermsteiner M, Vogel W. ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability. Pflugers Archiv : European Journal of Physiology. 1991;418(1-2):68-73. doi:10.1007/BF00370453
Jonas, P. M., Koh, D., Kampe, K., Hermsteiner, M., & Vogel, W. (1991). ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability. Pflugers Archiv : European Journal of Physiology, 418(1–2), 68–73. https://doi.org/10.1007/BF00370453
Jonas, Peter M, Duk Koh, Knut Kampe, Markus Hermsteiner, and Werner Vogel. “ATP-Sensitive and Ca-Activated K Channels in Vertebrate Axons: Novel Links between Metabolism and Excitability.” Pflugers Archiv : European Journal of Physiology 418, no. 1–2 (1991): 68–73. https://doi.org/10.1007/BF00370453.
P. M. Jonas, D. Koh, K. Kampe, M. Hermsteiner, and W. Vogel, “ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability,” Pflugers Archiv : European Journal of Physiology, vol. 418, no. 1–2, pp. 68–73, 1991.
Jonas PM, Koh D, Kampe K, Hermsteiner M, Vogel W. 1991. ATP-sensitive and Ca-activated K channels in vertebrate axons: novel links between metabolism and excitability. Pflugers Archiv : European Journal of Physiology. 418(1–2), 68–73.
Jonas, Peter M., et al. “ATP-Sensitive and Ca-Activated K Channels in Vertebrate Axons: Novel Links between Metabolism and Excitability.” Pflugers Archiv : European Journal of Physiology, vol. 418, no. 1–2, Springer, 1991, pp. 68–73, doi:10.1007/BF00370453.

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