Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels

P.M. Jonas, M. Bräu, M. Hermsteiner, W. Vogel, PNAS 86 (1989) 7238–7242.

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Abstract
Amphibian myelinated nerve fibers were treated with collagenase and protease. Axons with retraction of the myelin sheath were patch-clamped in the nodal and paranodal region. One type of Na channel was found. It has a single-channel conductance of 11 pS (15 degrees C) and is blocked by tetrodotoxin. Averaged events show the typical activation and inactivation kinetics of macroscopic Na current. Three potential-dependent K channels were identified (I, F, and S channel). The I channel, being the most frequent type, has a single-channel conductance of 23 pS (inward current, 105 mM K on both sides of the membrane), activates between -60 and -30 mV, deactivates with intermediate kinetics, and is sensitive to dendrotoxin. The F channel has a conductance of 30 pS, activates between -40 and 60 mV, and deactivates with fast kinetics. The former inactivates within tens of seconds; the latter inactivates within seconds. The third type, the S channel, has a conductance of 7 pS and deactivates slowly. All three channels can be blocked by external tetraethylammonium chloride. We suggest that these distinct K channel types form the basis for the different components of macroscopic K current described previously.
Publishing Year
Date Published
1989-09-01
Journal Title
PNAS
Volume
86
Issue
18
Page
7238 - 7242
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Jonas PM, Bräu M, Hermsteiner M, Vogel W. Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels. PNAS. 1989;86(18):7238-7242.
Jonas, P. M., Bräu, M., Hermsteiner, M., & Vogel, W. (1989). Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels. PNAS, 86(18), 7238–7242.
Jonas, Peter M, Michael Bräu, Markus Hermsteiner, and Werner Vogel. “Single-Channel Recording in Myelinated Nerve Fibers Reveals One Type of Na Channel but Different K Channels.” PNAS 86, no. 18 (1989): 7238–42.
P. M. Jonas, M. Bräu, M. Hermsteiner, and W. Vogel, “Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels,” PNAS, vol. 86, no. 18, pp. 7238–7242, 1989.
Jonas PM, Bräu M, Hermsteiner M, Vogel W. 1989. Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels. PNAS. 86(18), 7238–7242.
Jonas, Peter M., et al. “Single-Channel Recording in Myelinated Nerve Fibers Reveals One Type of Na Channel but Different K Channels.” PNAS, vol. 86, no. 18, National Academy of Sciences, 1989, pp. 7238–42.

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