--- _id: '3465' abstract: - lang: eng text: Asymmetrical displacement currents and Na currents of single myelinated nerve fibers of Xenopus laevis were studied in the temperature range from 5 to 24 degrees C. The time constant of the on-response at E = 4 mV, tau on, was strongly temperature dependent, whereas the amount of displaced charge at E = 39 mV, Qon, was only slightly temperature dependent. The mean Q10 for tau on-1 was 2.54, the mean Q10 for Qon was 1.07. The time constant of charge immobilization, tau i, at E = 4 mV varied significantly (alpha = 0.001) with temperature. The mean Q10 for tau i-1 was 2.71 +/- 0.38. The time constants of immobilization of gating charge and of fast inactivation of Na permeability were similar in the temperature range from 6 to 22 degrees C. The Qoff/Qon ratio for E = 4 mV pulses of 0.5 msec duration decreased with increasing temperature. The temperature dependence of the time constant of the off-response could not be described by a single Q10 value, since the Q10 depended on the duration of the test pulse. Increasing temperature shifted Qon (E) curves to more negative potentials by 0.51 mV K-1, but shifted PNa (E) curves and h infinity (E) curves to more positive potentials by 0.43 and 0.57 mV K-1, respectively. h infinity (E = -70 mV) increased monotonously with increasing temperature. The present data indicate that considerable entropy changes may occur when the Na channel molecule passes from closed through open to inactivated states. article_processing_charge: No article_type: original author: - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Jonas PM. Temperature dependence of gating current in myelinated nerve fibers. Journal of Membrane Biology. 1989;112(3):277-289. doi:10.1007/BF01870958 apa: Jonas, P. M. (1989). Temperature dependence of gating current in myelinated nerve fibers. Journal of Membrane Biology. Springer. https://doi.org/10.1007/BF01870958 chicago: Jonas, Peter M. “Temperature Dependence of Gating Current in Myelinated Nerve Fibers.” Journal of Membrane Biology. Springer, 1989. https://doi.org/10.1007/BF01870958. ieee: P. M. Jonas, “Temperature dependence of gating current in myelinated nerve fibers,” Journal of Membrane Biology, vol. 112, no. 3. Springer, pp. 277–289, 1989. ista: Jonas PM. 1989. Temperature dependence of gating current in myelinated nerve fibers. Journal of Membrane Biology. 112(3), 277–289. mla: Jonas, Peter M. “Temperature Dependence of Gating Current in Myelinated Nerve Fibers.” Journal of Membrane Biology, vol. 112, no. 3, Springer, 1989, pp. 277–89, doi:10.1007/BF01870958. short: P.M. Jonas, Journal of Membrane Biology 112 (1989) 277–289. date_created: 2018-12-11T12:03:28Z date_published: 1989-12-01T00:00:00Z date_updated: 2022-02-15T08:59:02Z day: '01' doi: 10.1007/BF01870958 extern: '1' external_id: pmid: - '2559205 ' intvolume: ' 112' issue: '3' language: - iso: eng main_file_link: - url: https://link.springer.com/article/10.1007/BF01870958 month: '12' oa_version: None page: 277 - 289 pmid: 1 publication: Journal of Membrane Biology publication_identifier: eissn: - 1432-1424 issn: - 0022-2631 publication_status: published publisher: Springer publist_id: '2922' quality_controlled: '1' scopus_import: '1' status: public title: Temperature dependence of gating current in myelinated nerve fibers type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 112 year: '1989' ...