---
_id: '3465'
abstract:
- lang: eng
text: Asymmetrical displacement currents and Na currents of single myelinated nerve
fibers of Xenopus laevis were studied in the temperature range from 5 to 24 degrees
C. The time constant of the on-response at E = 4 mV, tau on, was strongly temperature
dependent, whereas the amount of displaced charge at E = 39 mV, Qon, was only
slightly temperature dependent. The mean Q10 for tau on-1 was 2.54, the mean Q10
for Qon was 1.07. The time constant of charge immobilization, tau i, at E = 4
mV varied significantly (alpha = 0.001) with temperature. The mean Q10 for tau
i-1 was 2.71 +/- 0.38. The time constants of immobilization of gating charge and
of fast inactivation of Na permeability were similar in the temperature range
from 6 to 22 degrees C. The Qoff/Qon ratio for E = 4 mV pulses of 0.5 msec duration
decreased with increasing temperature. The temperature dependence of the time
constant of the off-response could not be described by a single Q10 value, since
the Q10 depended on the duration of the test pulse. Increasing temperature shifted
Qon (E) curves to more negative potentials by 0.51 mV K-1, but shifted PNa (E)
curves and h infinity (E) curves to more positive potentials by 0.43 and 0.57
mV K-1, respectively. h infinity (E = -70 mV) increased monotonously with increasing
temperature. The present data indicate that considerable entropy changes may occur
when the Na channel molecule passes from closed through open to inactivated states.
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Jonas PM. Temperature dependence of gating current in myelinated nerve fibers.
Journal of Membrane Biology. 1989;112(3):277-289. doi:10.1007/BF01870958
apa: Jonas, P. M. (1989). Temperature dependence of gating current in myelinated
nerve fibers. Journal of Membrane Biology. Springer. https://doi.org/10.1007/BF01870958
chicago: Jonas, Peter M. “Temperature Dependence of Gating Current in Myelinated
Nerve Fibers.” Journal of Membrane Biology. Springer, 1989. https://doi.org/10.1007/BF01870958.
ieee: P. M. Jonas, “Temperature dependence of gating current in myelinated nerve
fibers,” Journal of Membrane Biology, vol. 112, no. 3. Springer, pp. 277–289,
1989.
ista: Jonas PM. 1989. Temperature dependence of gating current in myelinated nerve
fibers. Journal of Membrane Biology. 112(3), 277–289.
mla: Jonas, Peter M. “Temperature Dependence of Gating Current in Myelinated Nerve
Fibers.” Journal of Membrane Biology, vol. 112, no. 3, Springer, 1989,
pp. 277–89, doi:10.1007/BF01870958.
short: P.M. Jonas, Journal of Membrane Biology 112 (1989) 277–289.
date_created: 2018-12-11T12:03:28Z
date_published: 1989-12-01T00:00:00Z
date_updated: 2022-02-15T08:59:02Z
day: '01'
doi: 10.1007/BF01870958
extern: '1'
external_id:
pmid:
- '2559205 '
intvolume: ' 112'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF01870958
month: '12'
oa_version: None
page: 277 - 289
pmid: 1
publication: Journal of Membrane Biology
publication_identifier:
eissn:
- 1432-1424
issn:
- 0022-2631
publication_status: published
publisher: Springer
publist_id: '2922'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Temperature dependence of gating current in myelinated nerve fibers
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 112
year: '1989'
...