{"publisher":"Springer","date_updated":"2022-02-15T08:59:02Z","publication_status":"published","extern":"1","article_processing_charge":"No","page":"277 - 289","type":"journal_article","year":"1989","pmid":1,"publist_id":"2922","external_id":{"pmid":["2559205 "]},"date_published":"1989-12-01T00:00:00Z","article_type":"original","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","language":[{"iso":"eng"}],"quality_controlled":"1","main_file_link":[{"url":"https://link.springer.com/article/10.1007/BF01870958"}],"doi":"10.1007/BF01870958","publication_identifier":{"issn":["0022-2631"],"eissn":["1432-1424"]},"month":"12","abstract":[{"lang":"eng","text":"Asymmetrical displacement currents and Na currents of single myelinated nerve fibers of Xenopus laevis were studied in the temperature range from 5 to 24 degrees C. The time constant of the on-response at E = 4 mV, tau on, was strongly temperature dependent, whereas the amount of displaced charge at E = 39 mV, Qon, was only slightly temperature dependent. The mean Q10 for tau on-1 was 2.54, the mean Q10 for Qon was 1.07. The time constant of charge immobilization, tau i, at E = 4 mV varied significantly (alpha = 0.001) with temperature. The mean Q10 for tau i-1 was 2.71 +/- 0.38. The time constants of immobilization of gating charge and of fast inactivation of Na permeability were similar in the temperature range from 6 to 22 degrees C. The Qoff/Qon ratio for E = 4 mV pulses of 0.5 msec duration decreased with increasing temperature. The temperature dependence of the time constant of the off-response could not be described by a single Q10 value, since the Q10 depended on the duration of the test pulse. Increasing temperature shifted Qon (E) curves to more negative potentials by 0.51 mV K-1, but shifted PNa (E) curves and h infinity (E) curves to more positive potentials by 0.43 and 0.57 mV K-1, respectively. h infinity (E = -70 mV) increased monotonously with increasing temperature. The present data indicate that considerable entropy changes may occur when the Na channel molecule passes from closed through open to inactivated states."}],"publication":"Journal of Membrane Biology","volume":112,"oa_version":"None","status":"public","_id":"3465","issue":"3","citation":{"ieee":"P. M. Jonas, “Temperature dependence of gating current in myelinated nerve fibers,” <i>Journal of Membrane Biology</i>, vol. 112, no. 3. Springer, pp. 277–289, 1989.","apa":"Jonas, P. M. (1989). Temperature dependence of gating current in myelinated nerve fibers. <i>Journal of Membrane Biology</i>. Springer. <a href=\"https://doi.org/10.1007/BF01870958\">https://doi.org/10.1007/BF01870958</a>","mla":"Jonas, Peter M. “Temperature Dependence of Gating Current in Myelinated Nerve Fibers.” <i>Journal of Membrane Biology</i>, vol. 112, no. 3, Springer, 1989, pp. 277–89, doi:<a href=\"https://doi.org/10.1007/BF01870958\">10.1007/BF01870958</a>.","ista":"Jonas PM. 1989. Temperature dependence of gating current in myelinated nerve fibers. Journal of Membrane Biology. 112(3), 277–289.","short":"P.M. Jonas, Journal of Membrane Biology 112 (1989) 277–289.","chicago":"Jonas, Peter M. “Temperature Dependence of Gating Current in Myelinated Nerve Fibers.” <i>Journal of Membrane Biology</i>. Springer, 1989. <a href=\"https://doi.org/10.1007/BF01870958\">https://doi.org/10.1007/BF01870958</a>.","ama":"Jonas PM. Temperature dependence of gating current in myelinated nerve fibers. <i>Journal of Membrane Biology</i>. 1989;112(3):277-289. doi:<a href=\"https://doi.org/10.1007/BF01870958\">10.1007/BF01870958</a>"},"scopus_import":"1","intvolume":"       112","date_created":"2018-12-11T12:03:28Z","author":[{"orcid":"0000-0001-5001-4804","last_name":"Jonas","full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M"}],"day":"01","title":"Temperature dependence of gating current in myelinated nerve fibers"}