Temperature dependence of gating current in myelinated nerve fibers

P.M. Jonas, Journal of Membrane Biology 112 (1989) 277–289.

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Abstract
Asymmetrical displacement currents and Na currents of single myelinated nerve fibers of Xenopus laevis were studied in the temperature range from 5 to 24 degrees C. The time constant of the on-response at E = 4 mV, tau on, was strongly temperature dependent, whereas the amount of displaced charge at E = 39 mV, Qon, was only slightly temperature dependent. The mean Q10 for tau on-1 was 2.54, the mean Q10 for Qon was 1.07. The time constant of charge immobilization, tau i, at E = 4 mV varied significantly (alpha = 0.001) with temperature. The mean Q10 for tau i-1 was 2.71 +/- 0.38. The time constants of immobilization of gating charge and of fast inactivation of Na permeability were similar in the temperature range from 6 to 22 degrees C. The Qoff/Qon ratio for E = 4 mV pulses of 0.5 msec duration decreased with increasing temperature. The temperature dependence of the time constant of the off-response could not be described by a single Q10 value, since the Q10 depended on the duration of the test pulse. Increasing temperature shifted Qon (E) curves to more negative potentials by 0.51 mV K-1, but shifted PNa (E) curves and h infinity (E) curves to more positive potentials by 0.43 and 0.57 mV K-1, respectively. h infinity (E = -70 mV) increased monotonously with increasing temperature. The present data indicate that considerable entropy changes may occur when the Na channel molecule passes from closed through open to inactivated states.
Publishing Year
Date Published
1989-12-01
Journal Title
Journal of Membrane Biology
Volume
112
Issue
3
Page
277 - 289
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Jonas PM. Temperature dependence of gating current in myelinated nerve fibers. Journal of Membrane Biology. 1989;112(3):277-289. doi:10.1007/BF01870958
Jonas, P. M. (1989). Temperature dependence of gating current in myelinated nerve fibers. Journal of Membrane Biology, 112(3), 277–289. https://doi.org/10.1007/BF01870958
Jonas, Peter M. “Temperature Dependence of Gating Current in Myelinated Nerve Fibers.” Journal of Membrane Biology 112, no. 3 (1989): 277–89. https://doi.org/10.1007/BF01870958.
P. M. Jonas, “Temperature dependence of gating current in myelinated nerve fibers,” Journal of Membrane Biology, vol. 112, no. 3, pp. 277–289, 1989.
Jonas PM. 1989. Temperature dependence of gating current in myelinated nerve fibers. Journal of Membrane Biology. 112(3), 277–289.
Jonas, Peter M. “Temperature Dependence of Gating Current in Myelinated Nerve Fibers.” Journal of Membrane Biology, vol. 112, no. 3, Springer, 1989, pp. 277–89, doi:10.1007/BF01870958.

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