Robust formation of morphogen gradients

M.T. Bollenbach, K. Kruse, P. Pantazis, M. González Gaitán, F. Jülicher, Physical Review Letters 94 (2005).


Journal Article | Published | English
Author
Bollenbach, TobiasIST Austria ; Kruse, Karsten; Pantazis, Periklis; González Gaitán, Marcos; Jülicher, Frank
Abstract
We discuss the formation of graded morphogen profiles in a cell layer by nonlinear transport phenomena, important for patterning developing organisms. We focus on a process termed transcytosis, where morphogen transport results from the binding of ligands to receptors on the cell surface, incorporation into the cell, and subsequent externalization. Starting from a microscopic model, we derive effective transport equations. We show that, in contrast to morphogen transport by extracellular diffusion, transcytosis leads to robust ligand profiles which are insensitive to the rate of ligand production.
Publishing Year
Date Published
2005-01-01
Journal Title
Physical Review Letters
Volume
94
Issue
1
IST-REx-ID

Cite this

Bollenbach MT, Kruse K, Pantazis P, González Gaitán M, Jülicher F. Robust formation of morphogen gradients. Physical Review Letters. 2005;94(1). doi:10.1103/PhysRevLett.94.018103
Bollenbach, M. T., Kruse, K., Pantazis, P., González Gaitán, M., & Jülicher, F. (2005). Robust formation of morphogen gradients. Physical Review Letters, 94(1). https://doi.org/10.1103/PhysRevLett.94.018103
Bollenbach, Mark Tobias, Karsten Kruse, Periklis Pantazis, Marcos González Gaitán, and Frank Jülicher. “Robust Formation of Morphogen Gradients.” Physical Review Letters 94, no. 1 (2005). https://doi.org/10.1103/PhysRevLett.94.018103.
M. T. Bollenbach, K. Kruse, P. Pantazis, M. González Gaitán, and F. Jülicher, “Robust formation of morphogen gradients,” Physical Review Letters, vol. 94, no. 1, 2005.
Bollenbach MT, Kruse K, Pantazis P, González Gaitán M, Jülicher F. 2005. Robust formation of morphogen gradients. Physical Review Letters. 94(1).
Bollenbach, Mark Tobias, et al. “Robust Formation of Morphogen Gradients.” Physical Review Letters, vol. 94, no. 1, American Physical Society, 2005, doi:10.1103/PhysRevLett.94.018103.
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