--- _id: '3374' abstract: - lang: eng text: Genetic regulatory networks enable cells to respond to changes in internal and external conditions by dynamically coordinating their gene expression profiles. Our ability to make quantitative measurements in these biochemical circuits has deepened our understanding of what kinds of computations genetic regulatory networks can perform, and with what reliability. These advances have motivated researchers to look for connections between the architecture and function of genetic regulatory networks. Transmitting information between a network's inputs and outputs has been proposed as one such possible measure of function, relevant in certain biological contexts. Here we summarize recent developments in the application of information theory to gene regulatory networks. We first review basic concepts in information theory necessary for understanding recent work. We then discuss the functional complexity of gene regulation, which arises from the molecular nature of the regulatory interactions. We end by reviewing some experiments that support the view that genetic networks responsible for early development of multicellular organisms might be maximizing transmitted 'positional information'. article_number: '153102' author: - first_name: Gasper full_name: Tkacik, Gasper id: 3D494DCA-F248-11E8-B48F-1D18A9856A87 last_name: Tkacik orcid: 0000-0002-6699-1455 - first_name: Aleksandra full_name: Walczak, Aleksandra last_name: Walczak citation: ama: 'Tkačik G, Walczak A. Information transmission in genetic regulatory networks a review. Journal of Physics: Condensed Matter. 2011;23(15). doi:10.1088/0953-8984/23/15/153102' apa: 'Tkačik, G., & Walczak, A. (2011). Information transmission in genetic regulatory networks a review. Journal of Physics: Condensed Matter. IOP Publishing Ltd. https://doi.org/10.1088/0953-8984/23/15/153102' chicago: 'Tkačik, Gašper, and Aleksandra Walczak. “Information Transmission in Genetic Regulatory Networks a Review.” Journal of Physics: Condensed Matter. IOP Publishing Ltd., 2011. https://doi.org/10.1088/0953-8984/23/15/153102.' ieee: 'G. Tkačik and A. Walczak, “Information transmission in genetic regulatory networks a review,” Journal of Physics: Condensed Matter, vol. 23, no. 15. IOP Publishing Ltd., 2011.' ista: 'Tkačik G, Walczak A. 2011. Information transmission in genetic regulatory networks a review. Journal of Physics: Condensed Matter. 23(15), 153102.' mla: 'Tkačik, Gašper, and Aleksandra Walczak. “Information Transmission in Genetic Regulatory Networks a Review.” Journal of Physics: Condensed Matter, vol. 23, no. 15, 153102, IOP Publishing Ltd., 2011, doi:10.1088/0953-8984/23/15/153102.' short: 'G. Tkačik, A. Walczak, Journal of Physics: Condensed Matter 23 (2011).' date_created: 2018-12-11T12:02:58Z date_published: 2011-04-01T00:00:00Z date_updated: 2021-01-12T07:43:03Z day: '01' department: - _id: GaTk doi: 10.1088/0953-8984/23/15/153102 intvolume: ' 23' issue: '15' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/1101.4240 month: '04' oa: 1 oa_version: Submitted Version publication: 'Journal of Physics: Condensed Matter' publication_status: published publisher: IOP Publishing Ltd. publist_id: '3233' quality_controlled: '1' scopus_import: 1 status: public title: Information transmission in genetic regulatory networks a review type: journal_article user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87 volume: 23 year: '2011' ...