---
res:
bibo_abstract:
- The chemical master equation is a differential equation describing the time evolution
of the probability distribution over the possible “states” of a biochemical system.
The solution of this equation is of interest within the systems biology field
ever since the importance of the molec- ular noise has been acknowledged. Unfortunately,
most of the systems do not have analytical solutions, and numerical solutions
suffer from the course of dimensionality and therefore need to be approximated.
Here, we introduce the concept of tail approximation, which retrieves an approximation
of the probabilities in the tail of a distribution from the total probability
of the tail and its conditional expectation. This approximation method can then
be used to numerically compute the solution of the chemical master equation on
a subset of the state space, thus fighting the explosion of the state space, for
which this problem is renowned.@eng
bibo_authorlist:
- foaf_Person:
foaf_givenName: Thomas A
foaf_name: Henzinger, Thomas A
foaf_surname: Henzinger
foaf_workInfoHomepage: http://www.librecat.org/personId=40876CD8-F248-11E8-B48F-1D18A9856A87
orcid: 0000−0002−2985−7724
- foaf_Person:
foaf_givenName: Maria
foaf_name: Mateescu, Maria
foaf_surname: Mateescu
dct_date: 2011^xs_gYear
dct_language: eng
dct_publisher: Tampere International Center for Signal Processing@
dct_title: Tail approximation for the chemical master equation@
...