{"publist_id":"3541","date_created":"2018-12-11T12:01:42Z","doi":"10.1016/j.devcel.2010.12.007","date_published":"2011-02-15T00:00:00Z","abstract":[{"text":"Regulated adhesion between cells and their environment is critical for normal cell migration. We have identified mutations in a gene encoding the Drosophila hydrogen peroxide (H2O2)-degrading enzyme Jafrac1, which lead to germ cell adhesion defects. During gastrulation, primordial germ cells (PGCs) associate tightly with the invaginating midgut primordium as it enters the embryo; however, in embryos from jafrac1 mutant mothers this association is disrupted, leaving some PGCs trailing on the outside of the embryo. We observed similar phenotypes in embryos from DE-cadherin/shotgun (shg) mutant mothers and were able to rescue the jafrac1 phenotype by increasing DE-cadherin levels. This and our biochemical evidence strongly suggest that Jafrac1-mediated reduction of H2O2 is required to maintain DE-cadherin protein levels in the early embryo. Our results present in vivo evidence of a peroxiredoxin regulating DE-cadherin-mediated adhesion.","lang":"eng"}],"citation":{"mla":"Degennaro, Matthew, et al. “Peroxiredoxin Stabilization of DE-Cadherin Promotes Primordial Germ Cell Adhesion.” <i>Developmental Cell</i>, vol. 20, no. 2, Cell Press, 2011, pp. 233–43, doi:<a href=\"https://doi.org/10.1016/j.devcel.2010.12.007\">10.1016/j.devcel.2010.12.007</a>.","short":"M. Degennaro, T. Hurd, D.E. Siekhaus, B. Biteau, H. Jasper, R. Lehmann, Developmental Cell 20 (2011) 233–243.","ieee":"M. Degennaro, T. Hurd, D. E. Siekhaus, B. Biteau, H. Jasper, and R. Lehmann, “Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion,” <i>Developmental Cell</i>, vol. 20, no. 2. Cell Press, pp. 233–243, 2011.","ista":"Degennaro M, Hurd T, Siekhaus DE, Biteau B, Jasper H, Lehmann R. 2011. Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion. Developmental Cell. 20(2), 233–243.","chicago":"Degennaro, Matthew, Thomas Hurd, Daria E Siekhaus, Benoit Biteau, Heinrich Jasper, and Ruth Lehmann. “Peroxiredoxin Stabilization of DE-Cadherin Promotes Primordial Germ Cell Adhesion.” <i>Developmental Cell</i>. Cell Press, 2011. <a href=\"https://doi.org/10.1016/j.devcel.2010.12.007\">https://doi.org/10.1016/j.devcel.2010.12.007</a>.","apa":"Degennaro, M., Hurd, T., Siekhaus, D. E., Biteau, B., Jasper, H., &#38; Lehmann, R. (2011). Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.devcel.2010.12.007\">https://doi.org/10.1016/j.devcel.2010.12.007</a>","ama":"Degennaro M, Hurd T, Siekhaus DE, Biteau B, Jasper H, Lehmann R. Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion. <i>Developmental Cell</i>. 2011;20(2):233-243. doi:<a href=\"https://doi.org/10.1016/j.devcel.2010.12.007\">10.1016/j.devcel.2010.12.007</a>"},"extern":1,"title":"Peroxiredoxin stabilization of DE-cadherin promotes primordial germ cell adhesion","intvolume":"        20","author":[{"full_name":"DeGennaro, Matthew","last_name":"Degennaro","first_name":"Matthew"},{"full_name":"Hurd, Thomas R","last_name":"Hurd","first_name":"Thomas"},{"first_name":"Daria E","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","full_name":"Daria Siekhaus","last_name":"Siekhaus","orcid":"0000-0001-8323-8353"},{"full_name":"Biteau, Benoit","last_name":"Biteau","first_name":"Benoit"},{"first_name":"Heinrich","last_name":"Jasper","full_name":"Jasper, Heinrich"},{"first_name":"Ruth","last_name":"Lehmann","full_name":"Lehmann, Ruth"}],"month":"02","publication_status":"published","day":"15","type":"journal_article","quality_controlled":0,"date_updated":"2021-01-12T07:41:26Z","page":"233 - 243","year":"2011","issue":"2","volume":20,"publication":"Developmental Cell","publisher":"Cell Press","_id":"3154","status":"public"}