--- _id: '3143' abstract: - lang: eng text: Two ETS transcription factors of the Pea3 subfamily are induced in subpopulations of dorsal root ganglion (DRG) sensory and spinal motor neurons by target-derived factors. Their expression controls late aspects of neuronal differentiation such as target invasion and branching. Here, we show that the late onset of ETS gene expression is an essential requirement for normal sensory neuron differentiation. We provide genetic evidence in the mouse that precocious ETS expression in DRG sensory neurons perturbs axonal projections, the acquisition of terminal differentiation markers, and their dependence on neurotrophic support. Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation. author: - first_name: Simon full_name: Simon Hippenmeyer id: 37B36620-F248-11E8-B48F-1D18A9856A87 last_name: Hippenmeyer orcid: 0000-0003-2279-1061 - first_name: Eline full_name: Vrieseling, Eline last_name: Vrieseling - first_name: Markus full_name: Sigrist, Markus last_name: Sigrist - first_name: Thomas full_name: Portmann, Thomas last_name: Portmann - first_name: Celia full_name: Laengle, Celia last_name: Laengle - first_name: David full_name: Ladle, David R last_name: Ladle - first_name: Silvia full_name: Arber, Silvia last_name: Arber citation: ama: Hippenmeyer S, Vrieseling E, Sigrist M, et al. A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biology. 2005;3(5):0878-0890. doi:10.1371/journal.pbio.0030159 apa: Hippenmeyer, S., Vrieseling, E., Sigrist, M., Portmann, T., Laengle, C., Ladle, D., & Arber, S. (2005). A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biology. Public Library of Science. https://doi.org/10.1371/journal.pbio.0030159 chicago: Hippenmeyer, Simon, Eline Vrieseling, Markus Sigrist, Thomas Portmann, Celia Laengle, David Ladle, and Silvia Arber. “A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling.” PLoS Biology. Public Library of Science, 2005. https://doi.org/10.1371/journal.pbio.0030159. ieee: S. Hippenmeyer et al., “A developmental switch in the response of DRG neurons to ETS transcription factor signaling,” PLoS Biology, vol. 3, no. 5. Public Library of Science, pp. 0878–0890, 2005. ista: Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle D, Arber S. 2005. A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biology. 3(5), 0878–0890. mla: Hippenmeyer, Simon, et al. “A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling.” PLoS Biology, vol. 3, no. 5, Public Library of Science, 2005, pp. 0878–90, doi:10.1371/journal.pbio.0030159. short: S. Hippenmeyer, E. Vrieseling, M. Sigrist, T. Portmann, C. Laengle, D. Ladle, S. Arber, PLoS Biology 3 (2005) 0878–0890. date_created: 2018-12-11T12:01:38Z date_published: 2005-05-01T00:00:00Z date_updated: 2021-01-12T07:41:21Z day: '01' doi: 10.1371/journal.pbio.0030159 extern: 1 intvolume: ' 3' issue: '5' month: '05' page: 0878 - 0890 publication: PLoS Biology publication_status: published publisher: Public Library of Science publist_id: '3552' quality_controlled: 0 status: public title: A developmental switch in the response of DRG neurons to ETS transcription factor signaling tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article volume: 3 year: '2005' ...