Control of neuronal phenotype: What targets tell the cell bodies

S. Hippenmeyer, I. Kramer, S. Arber, Trends in Neurosciences 27 (2004) 482–488.

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Book Review | Published
Author
Hippenmeyer, SimonIST Austria ; Kramer, Ina; Arber, Silvia
Abstract
Assembly of neuronal circuits is controlled by the sequential acquisition of neuronal subpopulation-specific identities at progressive developmental steps. Whereas neuronal features involved in initial phases of differentiation are already established at cell-cycle exit, recent findings, based mainly on work in the peripheral nervous system, suggest that the timely integration of signals encountered en route to targets and from the target region itself is essential to control late steps in connectivity. As neurons project towards their targets they require target-derived signals to establish mature axonal projections and acquire neuronal traits such as the expression of distinct combinations of neurotransmitters. Recent evidence presented in this review shows that this principle, of a signaling interplay between target-derived signals and neuronal cell bodies, is often mediated through transcriptional events and is evolutionarily conserved.
Publishing Year
Date Published
2004-08-01
Journal Title
Trends in Neurosciences
Volume
27
Issue
8
Page
482 - 488
IST-REx-ID

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Hippenmeyer S, Kramer I, Arber S. Control of neuronal phenotype: What targets tell the cell bodies. Trends in Neurosciences. 2004;27(8):482-488. doi:10.1016/j.tins.2004.05.012
Hippenmeyer, S., Kramer, I., & Arber, S. (2004). Control of neuronal phenotype: What targets tell the cell bodies. Trends in Neurosciences. Elsevier. https://doi.org/10.1016/j.tins.2004.05.012
Hippenmeyer, Simon, Ina Kramer, and Silvia Arber. “Control of Neuronal Phenotype: What Targets Tell the Cell Bodies.” Trends in Neurosciences. Elsevier, 2004. https://doi.org/10.1016/j.tins.2004.05.012.
S. Hippenmeyer, I. Kramer, and S. Arber, “Control of neuronal phenotype: What targets tell the cell bodies,” Trends in Neurosciences, vol. 27, no. 8. Elsevier, pp. 482–488, 2004.
Hippenmeyer S, Kramer I, Arber S. 2004. Control of neuronal phenotype: What targets tell the cell bodies. Trends in Neurosciences. 27(8), 482–488.
Hippenmeyer, Simon, et al. “Control of Neuronal Phenotype: What Targets Tell the Cell Bodies.” Trends in Neurosciences, vol. 27, no. 8, Elsevier, 2004, pp. 482–88, doi:10.1016/j.tins.2004.05.012.

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