TY - JOUR AB - Voltage-activated Ca(2+) channels (VACCs) mediate Ca(2+) influx to trigger action potential-evoked neurotransmitter release, but the mechanism by which Ca(2+) regulates spontaneous transmission is unclear. We found that VACCs are the major physiological triggers for spontaneous release at mouse neocortical inhibitory synapses. Moreover, despite the absence of a synchronizing action potential, we found that spontaneous fusion of a GABA-containing vesicle required the activation of multiple tightly coupled VACCs of variable type. AU - Williams, Courtney AU - Chen, Wenyan AU - Lee, Chia AU - Yaeger, Daniel AU - Vyleta, Nicholas AU - Smith, Stephen ID - 3121 IS - 9 JF - Nature Neuroscience TI - Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA VL - 15 ER -