[{"month":"09","language":[{}],"date_published":"2012-09-01T00:00:00Z","external_id":{"pmid":[]},"date_updated":"2021-01-12T07:41:12Z","day":"01","_id":"3121","creator":{"id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","login":"kschuh"},"acknowledgement":"The work was supported by the US National Institutes of Health (DA027110 and GM097433) and OCTRI. C.W. and N.P.V. were supported by a grant from the National Heart, Lung, and Blood Institute (T32HL033808).\r\nWe thank M. Andresen and K. Khodakhah for helpful comments. ","pmid":1,"quality_controlled":"1","volume":15,"dc":{"type":["info:eu-repo/semantics/article","doc-type:article","text","http://purl.org/coar/resource_type/c_6501"],"publisher":["Nature Publishing Group"],"source":["Williams C, Chen W, Lee C, Yaeger D, Vyleta N, Smith S. Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA. Nature Neuroscience. 2012;15(9):1195-1197. doi:10.1038/nn.3162"],"description":["Voltage-activated Ca(2+) channels (VACCs) mediate Ca(2+) influx to trigger action potential-evoked neurotransmitter release, but the mechanism by which Ca(2+) regulates spontaneous transmission is unclear. We found that VACCs are the major physiological triggers for spontaneous release at mouse neocortical inhibitory synapses. Moreover, despite the absence of a synchronizing action potential, we found that spontaneous fusion of a GABA-containing vesicle required the activation of multiple tightly coupled VACCs of variable type."],"language":["eng"],"rights":["info:eu-repo/semantics/openAccess"],"creator":["Williams, Courtney","Chen, Wenyan","Lee, Chia","Yaeger, Daniel","Vyleta, Nicholas","Smith, Stephen"],"date":["2012"],"title":["Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA"],"identifier":["https://research-explorer.ista.ac.at/record/3121"],"relation":["info:eu-repo/semantics/altIdentifier/doi/10.1038/nn.3162","info:eu-repo/semantics/altIdentifier/pmid/22842148"]},"scopus_import":1,"type":"journal_article","author":[{"first_name":"Courtney","last_name":"Williams"},{"first_name":"Wenyan","last_name":"Chen"},{"first_name":"Chia","last_name":"Lee"},{"first_name":"Daniel","last_name":"Yaeger"},{"id":"36C4978E-F248-11E8-B48F-1D18A9856A87","last_name":"Vyleta","first_name":"Nicholas"},{"last_name":"Smith","first_name":"Stephen"}],"intvolume":" 15","publication":"Nature Neuroscience","issue":"9","dini_type":"doc-type:article","uri_base":"https://research-explorer.ista.ac.at","publist_id":"3578","department":[{"tree":[{"_id":"ResearchGroups"},{"_id":"IST"}],"_id":"PeJo"}],"status":"public","publication_status":"published","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431448/"}],"oa_version":"Submitted Version","citation":{"chicago":"Williams, Courtney, Wenyan Chen, Chia Lee, Daniel Yaeger, Nicholas Vyleta, and Stephen Smith. “Coactivation of Multiple Tightly Coupled Calcium Channels Triggers Spontaneous Release of GABA.” Nature Neuroscience. Nature Publishing Group, 2012. https://doi.org/10.1038/nn.3162.","ista":"Williams C, Chen W, Lee C, Yaeger D, Vyleta N, Smith S. 2012. Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA. Nature Neuroscience. 15(9), 1195–1197.","apa":"Williams, C., Chen, W., Lee, C., Yaeger, D., Vyleta, N., & Smith, S. (2012). Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.3162","ieee":"C. Williams, W. Chen, C. Lee, D. Yaeger, N. Vyleta, and S. Smith, “Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA,” Nature Neuroscience, vol. 15, no. 9. Nature Publishing Group, pp. 1195–1197, 2012.","short":"C. Williams, W. Chen, C. Lee, D. Yaeger, N. Vyleta, S. Smith, Nature Neuroscience 15 (2012) 1195–1197.","mla":"Williams, Courtney, et al. “Coactivation of Multiple Tightly Coupled Calcium Channels Triggers Spontaneous Release of GABA.” Nature Neuroscience, vol. 15, no. 9, Nature Publishing Group, 2012, pp. 1195–97, doi:10.1038/nn.3162."},"date_created":"2018-12-11T12:01:30Z","abstract":[{"lang":"eng"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","oa":1,"page":"1195 - 1197"}]