--- res: bibo_abstract: - Voltage-activated Ca(2+) channels (VACCs) mediate Ca(2+) influx to trigger action potential-evoked neurotransmitter release, but the mechanism by which Ca(2+) regulates spontaneous transmission is unclear. We found that VACCs are the major physiological triggers for spontaneous release at mouse neocortical inhibitory synapses. Moreover, despite the absence of a synchronizing action potential, we found that spontaneous fusion of a GABA-containing vesicle required the activation of multiple tightly coupled VACCs of variable type.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Courtney foaf_name: Williams, Courtney foaf_surname: Williams - foaf_Person: foaf_givenName: Wenyan foaf_name: Chen, Wenyan foaf_surname: Chen - foaf_Person: foaf_givenName: Chia foaf_name: Lee, Chia foaf_surname: Lee - foaf_Person: foaf_givenName: Daniel foaf_name: Yaeger, Daniel foaf_surname: Yaeger - foaf_Person: foaf_givenName: Nicholas foaf_name: Vyleta, Nicholas foaf_surname: Vyleta foaf_workInfoHomepage: http://www.librecat.org/personId=36C4978E-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Stephen foaf_name: Smith, Stephen foaf_surname: Smith bibo_doi: 10.1038/nn.3162 bibo_issue: '9' bibo_volume: 15 dct_date: 2012^xs_gYear dct_language: eng dct_publisher: Nature Publishing Group@ dct_title: Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA@ fabio_hasPubmedId: '22842148' ...