--- _id: '3097' abstract: - lang: eng text: Cytokinin is an important regulator of plant growth and development. In Arabidopsis thaliana, the two-component phosphorelay mediated through a family of histidine kinases and response regulators is recognized as the principal cytokinin signal transduction mechanism activating the complex transcriptional response to control various developmental processes. Here, we identified an alternative mode of cytokinin action that uses endocytic trafficking as a means to direct plant organogenesis. This activity occurs downstream of known cytokinin receptors but through a branch of the cytokinin signaling pathway that does not involve transcriptional regulation. We show that cytokinin regulates endocytic recycling of the auxin efflux carrier PINFORMED1 (PIN1) by redirecting it for lytic degradation in vacuoles. Stimulation of the lytic PIN1 degradation is not a default effect for general downregulation of proteins from plasma membranes, but a specific mechanism to rapidly modulate the auxin distribution in cytokinin-mediated developmental processes. author: - first_name: Peter full_name: Peter Marhavy id: 3F45B078-F248-11E8-B48F-1D18A9856A87 last_name: Marhavy orcid: 0000-0001-5227-5741 - first_name: Agnieszka full_name: Bielach, Agnieszka last_name: Bielach - first_name: Lindy full_name: Abas, Lindy last_name: Abas - first_name: Anas full_name: Abuzeineh, Anas last_name: Abuzeineh - first_name: Jérôme full_name: Duclercq, Jérôme last_name: Duclercq - first_name: Hirokazu full_name: Tanaka, Hirokazu last_name: Tanaka - first_name: Markéta full_name: Pařezová, Markéta last_name: Pařezová - first_name: Jan full_name: Petrášek, Jan last_name: Petrášek - first_name: Jirí full_name: Jirí Friml id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Jürgen full_name: Kleine-Vehn, Jürgen last_name: Kleine Vehn - first_name: Eva full_name: Eva Benková id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 citation: ama: Marhavý P, Bielach A, Abas L, et al. Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis. Developmental Cell. 2011;21(4):796-804. doi:10.1016/j.devcel.2011.08.014 apa: Marhavý, P., Bielach, A., Abas, L., Abuzeineh, A., Duclercq, J., Tanaka, H., … Benková, E. (2011). Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2011.08.014 chicago: Marhavý, Peter, Agnieszka Bielach, Lindy Abas, Anas Abuzeineh, Jérôme Duclercq, Hirokazu Tanaka, Markéta Pařezová, et al. “Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis.” Developmental Cell. Cell Press, 2011. https://doi.org/10.1016/j.devcel.2011.08.014. ieee: P. Marhavý et al., “Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis,” Developmental Cell, vol. 21, no. 4. Cell Press, pp. 796–804, 2011. ista: Marhavý P, Bielach A, Abas L, Abuzeineh A, Duclercq J, Tanaka H, Pařezová M, Petrášek J, Friml J, Kleine Vehn J, Benková E. 2011. Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis. Developmental Cell. 21(4), 796–804. mla: Marhavý, Peter, et al. “Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis.” Developmental Cell, vol. 21, no. 4, Cell Press, 2011, pp. 796–804, doi:10.1016/j.devcel.2011.08.014. short: P. Marhavý, A. Bielach, L. Abas, A. Abuzeineh, J. Duclercq, H. Tanaka, M. Pařezová, J. Petrášek, J. Friml, J. Kleine Vehn, E. Benková, Developmental Cell 21 (2011) 796–804. date_created: 2018-12-11T12:01:22Z date_published: 2011-10-18T00:00:00Z date_updated: 2021-01-12T07:41:02Z day: '18' doi: 10.1016/j.devcel.2011.08.014 extern: 1 intvolume: ' 21' issue: '4' month: '10' page: 796 - 804 publication: Developmental Cell publication_status: published publisher: Cell Press publist_id: '3603' quality_controlled: 0 status: public title: Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis type: journal_article volume: 21 year: '2011' ...