---
_id: '3097'
abstract:
- lang: eng
text: Cytokinin is an important regulator of plant growth and development. In Arabidopsis
thaliana, the two-component phosphorelay mediated through a family of histidine
kinases and response regulators is recognized as the principal cytokinin signal
transduction mechanism activating the complex transcriptional response to control
various developmental processes. Here, we identified an alternative mode of cytokinin
action that uses endocytic trafficking as a means to direct plant organogenesis.
This activity occurs downstream of known cytokinin receptors but through a branch
of the cytokinin signaling pathway that does not involve transcriptional regulation.
We show that cytokinin regulates endocytic recycling of the auxin efflux carrier
PINFORMED1 (PIN1) by redirecting it for lytic degradation in vacuoles. Stimulation
of the lytic PIN1 degradation is not a default effect for general downregulation
of proteins from plasma membranes, but a specific mechanism to rapidly modulate
the auxin distribution in cytokinin-mediated developmental processes.
author:
- first_name: Peter
full_name: Peter Marhavy
id: 3F45B078-F248-11E8-B48F-1D18A9856A87
last_name: Marhavy
orcid: 0000-0001-5227-5741
- first_name: Agnieszka
full_name: Bielach, Agnieszka
last_name: Bielach
- first_name: Lindy
full_name: Abas, Lindy
last_name: Abas
- first_name: Anas
full_name: Abuzeineh, Anas
last_name: Abuzeineh
- first_name: Jérôme
full_name: Duclercq, Jérôme
last_name: Duclercq
- first_name: Hirokazu
full_name: Tanaka, Hirokazu
last_name: Tanaka
- first_name: Markéta
full_name: Pařezová, Markéta
last_name: Pařezová
- first_name: Jan
full_name: Petrášek, Jan
last_name: Petrášek
- first_name: Jirí
full_name: Jirí Friml
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Jürgen
full_name: Kleine-Vehn, Jürgen
last_name: Kleine Vehn
- first_name: Eva
full_name: Eva Benková
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
citation:
ama: Marhavý P, Bielach A, Abas L, et al. Cytokinin modulates endocytic trafficking
of PIN1 auxin efflux carrier to control plant organogenesis. Developmental
Cell. 2011;21(4):796-804. doi:10.1016/j.devcel.2011.08.014
apa: Marhavý, P., Bielach, A., Abas, L., Abuzeineh, A., Duclercq, J., Tanaka, H.,
… Benková, E. (2011). Cytokinin modulates endocytic trafficking of PIN1 auxin
efflux carrier to control plant organogenesis. Developmental Cell. Cell
Press. https://doi.org/10.1016/j.devcel.2011.08.014
chicago: Marhavý, Peter, Agnieszka Bielach, Lindy Abas, Anas Abuzeineh, Jérôme Duclercq,
Hirokazu Tanaka, Markéta Pařezová, et al. “Cytokinin Modulates Endocytic Trafficking
of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis.” Developmental
Cell. Cell Press, 2011. https://doi.org/10.1016/j.devcel.2011.08.014.
ieee: P. Marhavý et al., “Cytokinin modulates endocytic trafficking of PIN1
auxin efflux carrier to control plant organogenesis,” Developmental Cell,
vol. 21, no. 4. Cell Press, pp. 796–804, 2011.
ista: Marhavý P, Bielach A, Abas L, Abuzeineh A, Duclercq J, Tanaka H, Pařezová
M, Petrášek J, Friml J, Kleine Vehn J, Benková E. 2011. Cytokinin modulates endocytic
trafficking of PIN1 auxin efflux carrier to control plant organogenesis. Developmental
Cell. 21(4), 796–804.
mla: Marhavý, Peter, et al. “Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin
Efflux Carrier to Control Plant Organogenesis.” Developmental Cell, vol.
21, no. 4, Cell Press, 2011, pp. 796–804, doi:10.1016/j.devcel.2011.08.014.
short: P. Marhavý, A. Bielach, L. Abas, A. Abuzeineh, J. Duclercq, H. Tanaka, M.
Pařezová, J. Petrášek, J. Friml, J. Kleine Vehn, E. Benková, Developmental Cell
21 (2011) 796–804.
date_created: 2018-12-11T12:01:22Z
date_published: 2011-10-18T00:00:00Z
date_updated: 2021-01-12T07:41:02Z
day: '18'
doi: 10.1016/j.devcel.2011.08.014
extern: 1
intvolume: ' 21'
issue: '4'
month: '10'
page: 796 - 804
publication: Developmental Cell
publication_status: published
publisher: Cell Press
publist_id: '3603'
quality_controlled: 0
status: public
title: Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control
plant organogenesis
type: journal_article
volume: 21
year: '2011'
...