Emergence of tissue polarization from synergy of intracellular and extracellular auxin signaling

K.T. Wabnik, J. Kleine Vehn, J. Balla, M. Sauer, S. Naramoto, V. Reinöhl, R. Merks, W. Govaerts, J. Friml, Molecular Systems Biology 6 (2010).

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Abstract
Plant development is exceptionally flexible as manifested by its potential for organogenesis and regeneration, which are processes involving rearrangements of tissue polarities. Fundamental questions concern how individual cells can polarize in a coordinated manner to integrate into the multicellular context. In canalization models, the signaling molecule auxin acts as a polarizing cue, and feedback on the intercellular auxin flow is key for synchronized polarity rearrangements. We provide a novel mechanistic framework for canalization, based on up-to-date experimental data and minimal, biologically plausible assumptions. Our model combines the intracellular auxin signaling for expression of PINFORMED (PIN) auxin transporters and the theoretical postulation of extracellular auxin signaling for modulation of PIN subcellular dynamics. Computer simulations faithfully and robustly recapitulated the experimentally observed patterns of tissue polarity and asymmetric auxin distribution during formation and regeneration of vascular systems and during the competitive regulation of shoot branching by apical dominance. Additionally, our model generated new predictions that could be experimentally validated, highlighting a mechanistically conceivable explanation for the PIN polarization and canalization of the auxin flow in plants.
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Date Published
2010-12-21
Journal Title
Molecular Systems Biology
Volume
6
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Wabnik KT, Kleine Vehn J, Balla J, et al. Emergence of tissue polarization from synergy of intracellular and extracellular auxin signaling. Molecular Systems Biology. 2010;6. doi:10.1038/msb.2010.103
Wabnik, K. T., Kleine Vehn, J., Balla, J., Sauer, M., Naramoto, S., Reinöhl, V., … Friml, J. (2010). Emergence of tissue polarization from synergy of intracellular and extracellular auxin signaling. Molecular Systems Biology, 6. https://doi.org/10.1038/msb.2010.103
Wabnik, Krzysztof T, Jürgen Kleine Vehn, Jozef Balla, Michael Sauer, Satoshi Naramoto, Vilém Reinöhl, Roeland Merks, Willy Govaerts, and Jirí Friml. “Emergence of Tissue Polarization from Synergy of Intracellular and Extracellular Auxin Signaling.” Molecular Systems Biology 6 (2010). https://doi.org/10.1038/msb.2010.103.
K. T. Wabnik et al., “Emergence of tissue polarization from synergy of intracellular and extracellular auxin signaling,” Molecular Systems Biology, vol. 6, 2010.
Wabnik KT, Kleine Vehn J, Balla J, Sauer M, Naramoto S, Reinöhl V, Merks R, Govaerts W, Friml J. 2010. Emergence of tissue polarization from synergy of intracellular and extracellular auxin signaling. Molecular Systems Biology. 6.
Wabnik, Krzysztof T., et al. “Emergence of Tissue Polarization from Synergy of Intracellular and Extracellular Auxin Signaling.” Molecular Systems Biology, vol. 6, Nature Publishing Group, 2010, doi:10.1038/msb.2010.103.

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