Subcellular homeostasis of phytohormone auxin is mediated by the ER localized PIN5 transporter

J. Mravec, P. Skůpa, A. Bailly, K. Hoyerová, P. Křeček, A. Bielach, J. Petrášek, J. Zhang, V. Gaykova, Y. Stierhof, P. Dobrev, K. Schwarzerová, J. Rolčík, D. Seifertová, C. Luschnig, E. Benková, E. Zažímalová, M. Geisler, J. Friml, Nature 459 (2009) 1136–1140.

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Abstract
The plant signalling molecule auxin provides positional informa-tion in a variety of developmental processes by means of its differential distribution (gradients) within plant tissues. Thus, cellular auxin levels often determine the developmental output of auxin signalling. Conceptually, transmembrane transport and metabolic processes regulate the steady-state levels of auxin in any given cell2,3. In particular, PIN auxin-efflux-carrier-mediated, directional transport between cells is crucial for generating auxin gradients2,4,5. Here we show that Arabidopsis thaliana PIN5, an atypical member of the PIN gene family, encodes a functional auxin transporter that is required for auxin-mediated develop-ment. PIN5 does not have a direct role in cell-to-cell transport but regulates intracellular auxin homeostasis and metabolism. PIN5 localizes, unlike other characterized plasma membrane PIN proteins, to endoplasmic reticulum (ER), presumably medi-ating auxin flow from the cytosol to the lumen of the ER. The ER localization of other PIN5-like transporters (including the moss PIN) indicates that the diversification of PIN protein functions in mediating auxin homeostasis at the ER, and cell-to-cell auxin transport at the plasma membrane, represent an ancient event during the evolution of land plants.
Publishing Year
Date Published
2009-06-25
Journal Title
Nature
Volume
459
Issue
7250
Page
1136 - 1140
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Mravec J, Skůpa P, Bailly A, et al. Subcellular homeostasis of phytohormone auxin is mediated by the ER localized PIN5 transporter. Nature. 2009;459(7250):1136-1140. doi:10.1038/nature08066
Mravec, J., Skůpa, P., Bailly, A., Hoyerová, K., Křeček, P., Bielach, A., … Friml, J. (2009). Subcellular homeostasis of phytohormone auxin is mediated by the ER localized PIN5 transporter. Nature, 459(7250), 1136–1140. https://doi.org/10.1038/nature08066
Mravec, Jozef, Petr Skůpa, Aurélien Bailly, Klára Hoyerová, Pavel Křeček, Agnieszka Bielach, Jan Petrášek, et al. “Subcellular Homeostasis of Phytohormone Auxin Is Mediated by the ER Localized PIN5 Transporter.” Nature 459, no. 7250 (2009): 1136–40. https://doi.org/10.1038/nature08066.
J. Mravec et al., “Subcellular homeostasis of phytohormone auxin is mediated by the ER localized PIN5 transporter,” Nature, vol. 459, no. 7250, pp. 1136–1140, 2009.
Mravec J, Skůpa P, Bailly A, Hoyerová K, Křeček P, Bielach A, Petrášek J, Zhang J, Gaykova V, Stierhof Y, Dobrev P, Schwarzerová K, Rolčík J, Seifertová D, Luschnig C, Benková E, Zažímalová E, Geisler M, Friml J. 2009. Subcellular homeostasis of phytohormone auxin is mediated by the ER localized PIN5 transporter. Nature. 459(7250), 1136–1140.
Mravec, Jozef, et al. “Subcellular Homeostasis of Phytohormone Auxin Is Mediated by the ER Localized PIN5 Transporter.” Nature, vol. 459, no. 7250, Nature Publishing Group, 2009, pp. 1136–40, doi:10.1038/nature08066.

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