--- _id: '3044' abstract: - lang: eng text: 'The signalling molecule auxin controls plant morphogenesis via its activity gradients, which are produced by intercellular auxin transport. Cellular auxin efflux is the rate-limiting step in this process and depends on PIN and phosphoglycoprotein (PGP) auxin transporters. Mutual roles for these proteins in auxin transport are unclear, as is the significance of their interactions for plant development. Here, we have analysed the importance of the functional interaction between PIN- and PGP-dependent auxin transport in development. We show by analysis of inducible overexpression lines that PINs and PGPs define distinct auxin transport mechanisms: both mediate auxin efflux but they play diverse developmental roles. Components of both systems are expressed during embryogenesis, organogenesis and tropisms, and they interact genetically in both synergistic and antagonistic fashions. A concerted action of PIN- and PGP-dependent efflux systems is required for asymmetric auxin distribution during these processes. We propose a model in which PGP-mediated efflux controls auxin levels in auxin channel-forming cells and, thus, auxin availability for PIN-dependent vectorial auxin movement.' author: - first_name: Jozef full_name: Mravec, Jozef last_name: Mravec - first_name: Martin full_name: Kubeš, Martin last_name: Kubeš - first_name: Agnieszka full_name: Bielach, Agnieszka last_name: Bielach - first_name: Vassilena full_name: Gaykova, Vassilena last_name: Gaykova - first_name: Jan full_name: Petrášek, Jan last_name: Petrášek - first_name: Petr full_name: Skůpa, Petr last_name: Skůpa - first_name: Suresh full_name: Chand, Suresh last_name: Chand - first_name: Eva full_name: Eva Benková id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 - first_name: Eva full_name: Zažímalová, Eva last_name: Zažímalová - first_name: Jirí full_name: Jirí Friml id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Mravec J, Kubeš M, Bielach A, et al. Interaction of PIN and PGP transport mechanisms in auxin distribution-dependent development. Development. 2008;135(20):3345-3354. doi:10.1242/dev.021071 apa: Mravec, J., Kubeš, M., Bielach, A., Gaykova, V., Petrášek, J., Skůpa, P., … Friml, J. (2008). Interaction of PIN and PGP transport mechanisms in auxin distribution-dependent development. Development. Company of Biologists. https://doi.org/10.1242/dev.021071 chicago: Mravec, Jozef, Martin Kubeš, Agnieszka Bielach, Vassilena Gaykova, Jan Petrášek, Petr Skůpa, Suresh Chand, Eva Benková, Eva Zažímalová, and Jiří Friml. “Interaction of PIN and PGP Transport Mechanisms in Auxin Distribution-Dependent Development.” Development. Company of Biologists, 2008. https://doi.org/10.1242/dev.021071. ieee: J. Mravec et al., “Interaction of PIN and PGP transport mechanisms in auxin distribution-dependent development,” Development, vol. 135, no. 20. Company of Biologists, pp. 3345–3354, 2008. ista: Mravec J, Kubeš M, Bielach A, Gaykova V, Petrášek J, Skůpa P, Chand S, Benková E, Zažímalová E, Friml J. 2008. Interaction of PIN and PGP transport mechanisms in auxin distribution-dependent development. Development. 135(20), 3345–3354. mla: Mravec, Jozef, et al. “Interaction of PIN and PGP Transport Mechanisms in Auxin Distribution-Dependent Development.” Development, vol. 135, no. 20, Company of Biologists, 2008, pp. 3345–54, doi:10.1242/dev.021071. short: J. Mravec, M. Kubeš, A. Bielach, V. Gaykova, J. Petrášek, P. Skůpa, S. Chand, E. Benková, E. Zažímalová, J. Friml, Development 135 (2008) 3345–3354. date_created: 2018-12-11T12:01:02Z date_published: 2008-10-15T00:00:00Z date_updated: 2021-01-12T07:40:39Z day: '15' doi: 10.1242/dev.021071 extern: 1 intvolume: ' 135' issue: '20' month: '10' page: 3345 - 3354 publication: Development publication_status: published publisher: Company of Biologists publist_id: '3658' quality_controlled: 0 status: public title: Interaction of PIN and PGP transport mechanisms in auxin distribution-dependent development type: journal_article volume: 135 year: '2008' ...