---
_id: '3028'
abstract:
- lang: eng
text: In plants, cell polarity and tissue patterning are connected by intercellular
flow of the phytohormone auxin, whose directional signaling depends on polar subcellular
localization of PIN auxin transport proteins. The mechanism of polar targeting
of PINs or other cargos in plants is largely unidentified, with the PINOID kinase
being the only known molecular component. Here, we identify PP2A phosphatase as
an important regulator of PIN apical-basal targeting and auxin distribution. Genetic
analysis, localization, and phosphorylation studies demonstrate that PP2A and
PINOID both partially colocalize with PINs and act antagonistically on the phosphorylation
state of their central hydrophilic loop, hence mediating PIN apical-basal polar
targeting. Thus, in plants, polar sorting by the reversible phosphorylation of
cargos allows for their conditional delivery to specific intracellular destinations.
In the case of PIN proteins, this mechanism enables switches in the direction
of intercellular auxin fluxes, which mediate differential growth, tissue patterning,
and organogenesis.
author:
- first_name: Marta
full_name: Michniewicz, Marta
last_name: Michniewicz
- first_name: Marcelo
full_name: Zago, Marcelo K
last_name: Zago
- first_name: Lindy
full_name: Abas, Lindy
last_name: Abas
- first_name: Dolf
full_name: Weijers, Dolf
last_name: Weijers
- first_name: Alois
full_name: Schweighofer, Alois
last_name: Schweighofer
- first_name: Irute
full_name: Meskiene, Irute
last_name: Meskiene
- first_name: Marcus
full_name: Heisler, Marcus G
last_name: Heisler
- first_name: Carolyn
full_name: Ohno, Carolyn
last_name: Ohno
- first_name: Jing
full_name: Zhang, Jing
last_name: Zhang
- first_name: Fang
full_name: Huang, Fang
last_name: Huang
- first_name: Rebecca
full_name: Schwab, Rebecca
last_name: Schwab
- first_name: Detlef
full_name: Weigel, Detlef
last_name: Weigel
- first_name: Elliot
full_name: Meyerowitz, Elliot M
last_name: Meyerowitz
- first_name: Christian
full_name: Luschnig, Christian
last_name: Luschnig
- first_name: Remko
full_name: Offringa, Remko
last_name: Offringa
- first_name: Jirí
full_name: Jirí Friml
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Michniewicz M, Zago M, Abas L, et al. Antagonistic regulation of PIN phosphorylation
by PP2A and PINOID directs auxin flux. Cell. 2007;130(6):1044-1056. doi:10.1016/j.cell.2007.07.033
apa: Michniewicz, M., Zago, M., Abas, L., Weijers, D., Schweighofer, A., Meskiene,
I., … Friml, J. (2007). Antagonistic regulation of PIN phosphorylation by PP2A
and PINOID directs auxin flux. Cell. Cell Press. https://doi.org/10.1016/j.cell.2007.07.033
chicago: Michniewicz, Marta, Marcelo Zago, Lindy Abas, Dolf Weijers, Alois Schweighofer,
Irute Meskiene, Marcus Heisler, et al. “Antagonistic Regulation of PIN Phosphorylation
by PP2A and PINOID Directs Auxin Flux.” Cell. Cell Press, 2007. https://doi.org/10.1016/j.cell.2007.07.033.
ieee: M. Michniewicz et al., “Antagonistic regulation of PIN phosphorylation
by PP2A and PINOID directs auxin flux,” Cell, vol. 130, no. 6. Cell Press,
pp. 1044–1056, 2007.
ista: Michniewicz M, Zago M, Abas L, Weijers D, Schweighofer A, Meskiene I, Heisler
M, Ohno C, Zhang J, Huang F, Schwab R, Weigel D, Meyerowitz E, Luschnig C, Offringa
R, Friml J. 2007. Antagonistic regulation of PIN phosphorylation by PP2A and PINOID
directs auxin flux. Cell. 130(6), 1044–1056.
mla: Michniewicz, Marta, et al. “Antagonistic Regulation of PIN Phosphorylation
by PP2A and PINOID Directs Auxin Flux.” Cell, vol. 130, no. 6, Cell Press,
2007, pp. 1044–56, doi:10.1016/j.cell.2007.07.033.
short: M. Michniewicz, M. Zago, L. Abas, D. Weijers, A. Schweighofer, I. Meskiene,
M. Heisler, C. Ohno, J. Zhang, F. Huang, R. Schwab, D. Weigel, E. Meyerowitz,
C. Luschnig, R. Offringa, J. Friml, Cell 130 (2007) 1044–1056.
date_created: 2018-12-11T12:00:57Z
date_published: 2007-09-21T00:00:00Z
date_updated: 2021-01-12T07:40:33Z
day: '21'
doi: 10.1016/j.cell.2007.07.033
extern: 1
intvolume: ' 130'
issue: '6'
month: '09'
page: 1044 - 1056
publication: Cell
publication_status: published
publisher: Cell Press
publist_id: '3674'
quality_controlled: 0
status: public
title: Antagonistic regulation of PIN phosphorylation by PP2A and PINOID directs auxin
flux
type: journal_article
volume: 130
year: '2007'
...