{"alternative_title":["Biochemical Society Transactions"],"abstract":[{"lang":"eng","text":"Polarized transport of the plant hormone auxin influences multiple growth processes in plants and is regulated by plasma-membrane-localized efflux and uptake carriers. The PGP (P-glycoprotein) ABC transporters (ATP-binding-cassette transporters), PIN (pin-formed) subfamily of major facilitator proteins and members of AUX/LAX families have been shown to independently transport auxin both in planta and in heterologous systems. However, PIN- and PGP-mediated transport in heterologous systems exhibits decreased substrate specificity and inhibitor-sensitivity compared with what is seen in plants and plant cells. To determine whether PIN-PGP interactions enhance transport specificity, we analysed interactions of the representative auxin-transporting PGPs with PIN1 and AUX1 in planta and in heterologous systems. Here, we provide evidence that PINs and PGPs interact and function both independently and co-ordinately to control polar auxin transport and impart transport specificity and directionality. These interactions take place in protein complexes stabilized by PGPs in detergent-resistant microdomains."}],"volume":35,"publist_id":"3681","date_updated":"2021-01-12T07:40:30Z","status":"public","date_created":"2018-12-11T12:00:54Z","conference":{"name":"Intercellular Signalling in Plants"},"author":[{"full_name":"Bandyopadhyay, Anindita","first_name":"Anindita","last_name":"Bandyopadhyay"},{"full_name":"Blakeslee, Joshua","last_name":"Blakeslee","first_name":"Joshua"},{"full_name":"Lee, Ok Ran","first_name":"Ok","last_name":"Lee"},{"full_name":"Mravec, Jozef","last_name":"Mravec","first_name":"Jozef"},{"full_name":"Sauer, Michael","first_name":"Michael","last_name":"Sauer"},{"full_name":"Titapiwatanakun, Boosaree","first_name":"Boosaree","last_name":"Titapiwatanakun"},{"last_name":"Makam","first_name":"Srinivas","full_name":"Makam, Srinivas N"},{"full_name":"Bouchard, Rodolphe","first_name":"Rodolphe","last_name":"Bouchard"},{"first_name":"Markus","last_name":"Geisler","full_name":"Geisler, Markus"},{"full_name":"Martinoia, Enrico","first_name":"Enrico","last_name":"Martinoia"},{"orcid":"0000-0002-8302-7596","first_name":"Jirí","last_name":"Friml","full_name":"Jirí Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Peer","first_name":"Wendy","full_name":"Peer, Wendy A"},{"first_name":"Angus","last_name":"Murphy","full_name":"Murphy, Angus S"}],"publication_status":"published","issue":"1","_id":"3021","type":"conference","doi":"10.1042/BST0350137","page":"137 - 141","intvolume":"        35","extern":1,"date_published":"2007-02-01T00:00:00Z","citation":{"ama":"Bandyopadhyay A, Blakeslee J, Lee O, et al. Interactions of PIN and PGP auxin transport mechanisms. In: Vol 35. Portland Press; 2007:137-141. doi:<a href=\"https://doi.org/10.1042/BST0350137\">10.1042/BST0350137</a>","ieee":"A. Bandyopadhyay <i>et al.</i>, “Interactions of PIN and PGP auxin transport mechanisms,” presented at the Intercellular Signalling in Plants, 2007, vol. 35, no. 1, pp. 137–141.","short":"A. Bandyopadhyay, J. Blakeslee, O. Lee, J. Mravec, M. Sauer, B. Titapiwatanakun, S. Makam, R. Bouchard, M. Geisler, E. Martinoia, J. Friml, W. Peer, A. Murphy, in:, Portland Press, 2007, pp. 137–141.","mla":"Bandyopadhyay, Anindita, et al. <i>Interactions of PIN and PGP Auxin Transport Mechanisms</i>. Vol. 35, no. 1, Portland Press, 2007, pp. 137–41, doi:<a href=\"https://doi.org/10.1042/BST0350137\">10.1042/BST0350137</a>.","apa":"Bandyopadhyay, A., Blakeslee, J., Lee, O., Mravec, J., Sauer, M., Titapiwatanakun, B., … Murphy, A. (2007). Interactions of PIN and PGP auxin transport mechanisms (Vol. 35, pp. 137–141). Presented at the Intercellular Signalling in Plants, Portland Press. <a href=\"https://doi.org/10.1042/BST0350137\">https://doi.org/10.1042/BST0350137</a>","ista":"Bandyopadhyay A, Blakeslee J, Lee O, Mravec J, Sauer M, Titapiwatanakun B, Makam S, Bouchard R, Geisler M, Martinoia E, Friml J, Peer W, Murphy A. 2007. Interactions of PIN and PGP auxin transport mechanisms. Intercellular Signalling in Plants, Biochemical Society Transactions, vol. 35, 137–141.","chicago":"Bandyopadhyay, Anindita, Joshua Blakeslee, Ok Lee, Jozef Mravec, Michael Sauer, Boosaree Titapiwatanakun, Srinivas Makam, et al. “Interactions of PIN and PGP Auxin Transport Mechanisms,” 35:137–41. Portland Press, 2007. <a href=\"https://doi.org/10.1042/BST0350137\">https://doi.org/10.1042/BST0350137</a>."},"quality_controlled":0,"title":"Interactions of PIN and PGP auxin transport mechanisms","publisher":"Portland Press","day":"01","month":"02","year":"2007"}