A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux

J. Friml, X. Yang, M. Michniewicz, D. Weijers, A. Quint, O. Tietz, R. Benjamins, P. Ouwerkerk, K. Ljung, G. Sandberg, P. Hooykaas, K. Palme, R. Offringa, Science 306 (2004) 862–865.

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Journal Article | Published
Author
Friml, JiríIST Austria ; Yang, Xiong; Michniewicz, Marta; Weijers, Dolf; Quint, Ab; Tietz, Olaf; Benjamins, René; Ouwerkerk, Pieter B; Ljung, Karin; Sandberg, Göran; Hooykaas, Paul J; Palme, Klaus
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Abstract
Polar transport-dependent local accumulation of auxin provides positional cues for multiple plant patterning processes. This directional auxin flow depends on the polar subcellular localization of the PIN auxin efflux regulators. Overexpression of the PINOID protein kinase induces a basal-to-apical shift in PIN localization, resulting in the loss of auxin gradients and strong defects in embryo and seedling roots. Conversely, pid loss of function induces an apical-to-basal shift in PIN1 polar targeting at the inflorescence apex, accompanied by defective organogenesis. Our results show that a PINOID-dependent binary switch controls PIN polarity and mediates changes in auxin flow to create local gradients for patterning processes.
Publishing Year
Date Published
2004-10-29
Journal Title
Science
Volume
306
Issue
5697
Page
862 - 865
IST-REx-ID

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Friml J, Yang X, Michniewicz M, et al. A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux. Science. 2004;306(5697):862-865. doi:10.1126/science.1100618
Friml, J., Yang, X., Michniewicz, M., Weijers, D., Quint, A., Tietz, O., … Offringa, R. (2004). A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux. Science, 306(5697), 862–865. https://doi.org/10.1126/science.1100618
Friml, Jirí, Xiong Yang, Marta Michniewicz, Dolf Weijers, Ab Quint, Olaf Tietz, René Benjamins, et al. “A PINOID-Dependent Binary Switch in Apical-Basal PIN Polar Targeting Directs Auxin Efflux.” Science 306, no. 5697 (2004): 862–65. https://doi.org/10.1126/science.1100618.
J. Friml et al., “A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux,” Science, vol. 306, no. 5697, pp. 862–865, 2004.
Friml J, Yang X, Michniewicz M, Weijers D, Quint A, Tietz O, Benjamins R, Ouwerkerk P, Ljung K, Sandberg G, Hooykaas P, Palme K, Offringa R. 2004. A PINOID-dependent binary switch in apical-basal PIN polar targeting directs auxin efflux. Science. 306(5697), 862–865.
Friml, Jirí, et al. “A PINOID-Dependent Binary Switch in Apical-Basal PIN Polar Targeting Directs Auxin Efflux.” Science, vol. 306, no. 5697, American Association for the Advancement of Science, 2004, pp. 862–65, doi:10.1126/science.1100618.

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