---
_id: '2897'
acknowledgement: TFs regulate gene expression by binding to specific sequences in
the promoter regions of their target genes. Promoters often contain multiple copies
of the same TF binding sites. How does this multiplicity evolve? One possibility
is that individuals with multiple, redundant binding sites have higher fitness.
However, nonadaptive processes are also likely to be important. Here, we develop
a mathematical model of the evolution of TF binding sites to help us disentangle
how different evolutionary mechanisms contribute to the evolution of binding site
redundancy and multiplicity. We show that recombination is expected to promote the
evolution of multiple binding sites. This prediction is corroborated by genome-wide
data from yeast. Another important factor in the evolution of multiplicity predicted
in our analysis is TF promiscuity, that is, the ability of a TF to bind to multiple
sequences. In addition, our analysis indicated that direct selection can have large
effects on the evolution of redundancy and multiplicity. Data from yeast identified
selection for changes in expression level as a candidate mechanism for the evolution
of multiple binding sites. We conclude that, although selection may play a major
role in the evolution of multiplicity in regulatory regions, nonadaptive forces
can also lead to high levels of multiplicity.
author:
- first_name: Tiago
full_name: Tiago Paixao
id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
last_name: Paixao
orcid: 0000-0003-2361-3953
- first_name: Ricardo
full_name: Azevedo, Ricardo B
last_name: Azevedo
citation:
ama: Paixao T, Azevedo R. Redundancy and the Evolution of Cis Regulatory Element
Multiplicity. PLoS Computational Biology. 2011;6(7). doi:10.1371/journal.pcbi.1000848
apa: Paixao, T., & Azevedo, R. (2011). Redundancy and the Evolution of Cis Regulatory
Element Multiplicity. PLoS Computational Biology. Public Library of Science.
https://doi.org/10.1371/journal.pcbi.1000848
chicago: Paixao, Tiago, and Ricardo Azevedo. “Redundancy and the Evolution of Cis
Regulatory Element Multiplicity.” PLoS Computational Biology. Public Library
of Science, 2011. https://doi.org/10.1371/journal.pcbi.1000848.
ieee: T. Paixao and R. Azevedo, “Redundancy and the Evolution of Cis Regulatory
Element Multiplicity,” PLoS Computational Biology, vol. 6, no. 7. Public
Library of Science, 2011.
ista: Paixao T, Azevedo R. 2011. Redundancy and the Evolution of Cis Regulatory
Element Multiplicity. PLoS Computational Biology. 6(7).
mla: Paixao, Tiago, and Ricardo Azevedo. “Redundancy and the Evolution of Cis Regulatory
Element Multiplicity.” PLoS Computational Biology, vol. 6, no. 7, Public
Library of Science, 2011, doi:10.1371/journal.pcbi.1000848.
short: T. Paixao, R. Azevedo, PLoS Computational Biology 6 (2011).
date_created: 2018-12-11T12:00:13Z
date_published: 2011-01-01T00:00:00Z
date_updated: 2021-01-12T07:00:33Z
day: '01'
doi: 10.1371/journal.pcbi.1000848
extern: 1
intvolume: ' 6'
issue: '7'
license: https://creativecommons.org/licenses/by/4.0/
month: '01'
publication: PLoS Computational Biology
publication_status: published
publisher: Public Library of Science
publist_id: '3861'
quality_controlled: 0
status: public
title: Redundancy and the Evolution of Cis Regulatory Element Multiplicity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
volume: 6
year: '2011'
...