--- res: bibo_abstract: - Lateral root (LR) formation is initiated when pericycle cells accumulate auxin, thereby acquiring founder cell (FC) status and triggering asymmetric cell divisions, giving rise to a new primordium. How this auxin maximum in pericycle cells builds up and remains focused is not understood. We report that the endodermis plays an active role in the regulation of auxin accumulation and is instructive for FCs to progress during the LR initiation (LRI) phase. We describe the functional importance of a PIN3 (PIN-formed) auxin efflux carrier-dependent hormone reflux pathway between overlaying endodermal and pericycle FCs. Disrupting this reflux pathway causes dramatic defects in the progress of FCs towards the next initiation phase. Our data identify an unexpected regulatory function for the endodermis in LRI as part of the fine-tuning mechanism that appears to act as a check point in LR organogenesis after FCs are specified.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Peter foaf_name: Marhavy, Peter foaf_surname: Marhavy foaf_workInfoHomepage: http://www.librecat.org/personId=3F45B078-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-5227-5741 - foaf_Person: foaf_givenName: Marleen foaf_name: Vanstraelen, Marleen foaf_surname: Vanstraelen - foaf_Person: foaf_givenName: Bert foaf_name: De Rybel, Bert foaf_surname: De Rybel - foaf_Person: foaf_givenName: Ding foaf_name: Zhaojun, Ding foaf_surname: Zhaojun - foaf_Person: foaf_givenName: Malcolm foaf_name: Bennett, Malcolm foaf_surname: Bennett - foaf_Person: foaf_givenName: Tom foaf_name: Beeckman, Tom foaf_surname: Beeckman - foaf_Person: foaf_givenName: Eva foaf_name: Benková, Eva foaf_surname: Benková foaf_workInfoHomepage: http://www.librecat.org/personId=38F4F166-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8510-9739 bibo_doi: 10.1038/emboj.2012.303 bibo_issue: '1' bibo_volume: 32 dct_date: 2013^xs_gYear dct_language: eng dct_publisher: Wiley-Blackwell@ dct_title: Auxin reflux between the endodermis and pericycle promotes lateral root initiation@ fabio_hasPubmedId: '23178590' ...