Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants

G. Krouk, B. Lacombe, A. Bielach, F. Perrine Walker, K. Malínská, E. Mounier, K. Hoyerová, P. Tillard, S. Leon, K. Ljung, E. Zažímalová, E. Benková, P. Nacry, A. Gojon, Developmental Cell 18 (2010) 927–937.

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Abstract
Nitrate is both a nitrogen source for higher plants and a signal molecule regulating their development. In Arabidopsis, the NRT1.1 nitrate transporter is crucial for nitrate signaling governing root growth, and has been proposed to act as a nitrate sensor. However, the sensing mechanism is unknown. Herein we show that NRT1.1 not only transports nitrate but also facilitates uptake of the phytohormone auxin. Moreover, nitrate inhibits NRT1.1-dependent auxin uptake, suggesting that transduction of nitrate signal by NRT1.1 is associated with a modification of auxin transport. Among other effects, auxin stimulates lateral root development. Mutation of NRT1.1 enhances both auxin accumulation in lateral roots and growth of these roots at low, but not high, nitrate concentration. Thus, we propose that NRT1.1 represses lateral root growth at low nitrate availability by promoting basipetal auxin transport out of these roots. This defines a mechanism connecting nutrient and hormone signaling during organ development.
Publishing Year
Date Published
2010-06-15
Journal Title
Developmental Cell
Volume
18
Issue
6
Page
927 - 937
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Krouk G, Lacombe B, Bielach A, et al. Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants. Developmental Cell. 2010;18(6):927-937. doi:10.1016/j.devcel.2010.05.008
Krouk, G., Lacombe, B., Bielach, A., Perrine Walker, F., Malínská, K., Mounier, E., … Gojon, A. (2010). Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants. Developmental Cell, 18(6), 927–937. https://doi.org/10.1016/j.devcel.2010.05.008
Krouk, Gabriel, Benoît Lacombe, Agnieszka Bielach, Francine Perrine Walker, Kateřina Malínská, Emmanuelle Mounier, Klára Hoyerová, et al. “Nitrate-Regulated Auxin Transport by NRT1.1 Defines a Mechanism for Nutrient Sensing in Plants.” Developmental Cell 18, no. 6 (2010): 927–37. https://doi.org/10.1016/j.devcel.2010.05.008.
G. Krouk et al., “Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants,” Developmental Cell, vol. 18, no. 6, pp. 927–937, 2010.
Krouk G, Lacombe B, Bielach A, Perrine Walker F, Malínská K, Mounier E, Hoyerová K, Tillard P, Leon S, Ljung K, Zažímalová E, Benková E, Nacry P, Gojon A. 2010. Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants. Developmental Cell. 18(6), 927–937.
Krouk, Gabriel, et al. “Nitrate-Regulated Auxin Transport by NRT1.1 Defines a Mechanism for Nutrient Sensing in Plants.” Developmental Cell, vol. 18, no. 6, Cell Press, 2010, pp. 927–37, doi:10.1016/j.devcel.2010.05.008.

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