{"day":"16","publisher":"Public Library of Science","volume":8,"year":"2013","oa":1,"language":[{"iso":"eng"}],"publication_status":"published","license":"https://creativecommons.org/licenses/by/4.0/","pubrep_id":"407","publist_id":"3960","doi":"10.1371/journal.pone.0054285","issue":"1","file":[{"file_size":4795977,"date_created":"2018-12-12T10:15:38Z","content_type":"application/pdf","file_id":"5160","relation":"main_file","checksum":"512733b21419574a45f10cabef3d7f81","date_updated":"2020-07-14T12:45:50Z","creator":"system","access_level":"open_access","file_name":"IST-2016-407-v1+1_journal.pone.0054285.pdf"}],"article_number":"e54285","date_updated":"2021-01-12T07:00:07Z","_id":"2838","publication":"PLoS One","month":"01","type":"journal_article","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","file_date_updated":"2020-07-14T12:45:50Z","date_published":"2013-01-16T00:00:00Z","date_created":"2018-12-11T11:59:52Z","oa_version":"Published Version","title":"Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: Possible role in Down syndrome","status":"public","ddc":["570"],"citation":{"chicago":"Arquè Fuste, Gloria, Anna Casanovas, and Mara Dierssen. “Dyrk1A Is Dynamically Expressed on Subsets of Motor Neurons and in the Neuromuscular Junction: Possible Role in Down Syndrome.” <i>PLoS One</i>. Public Library of Science, 2013. <a href=\"https://doi.org/10.1371/journal.pone.0054285\">https://doi.org/10.1371/journal.pone.0054285</a>.","ieee":"G. Arquè Fuste, A. Casanovas, and M. Dierssen, “Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: Possible role in Down syndrome,” <i>PLoS One</i>, vol. 8, no. 1. Public Library of Science, 2013.","apa":"Arquè Fuste, G., Casanovas, A., &#38; Dierssen, M. (2013). Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: Possible role in Down syndrome. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0054285\">https://doi.org/10.1371/journal.pone.0054285</a>","mla":"Arquè Fuste, Gloria, et al. “Dyrk1A Is Dynamically Expressed on Subsets of Motor Neurons and in the Neuromuscular Junction: Possible Role in Down Syndrome.” <i>PLoS One</i>, vol. 8, no. 1, e54285, Public Library of Science, 2013, doi:<a href=\"https://doi.org/10.1371/journal.pone.0054285\">10.1371/journal.pone.0054285</a>.","ista":"Arquè Fuste G, Casanovas A, Dierssen M. 2013. Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: Possible role in Down syndrome. PLoS One. 8(1), e54285.","short":"G. Arquè Fuste, A. Casanovas, M. Dierssen, PLoS One 8 (2013).","ama":"Arquè Fuste G, Casanovas A, Dierssen M. Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: Possible role in Down syndrome. <i>PLoS One</i>. 2013;8(1). doi:<a href=\"https://doi.org/10.1371/journal.pone.0054285\">10.1371/journal.pone.0054285</a>"},"intvolume":"         8","author":[{"id":"3CF33908-F248-11E8-B48F-1D18A9856A87","first_name":"Gloria","last_name":"Arquè Fuste","full_name":"Arquè Fuste, Gloria"},{"last_name":"Casanovas","full_name":"Casanovas, Anna","first_name":"Anna"},{"first_name":"Mara","full_name":"Dierssen, Mara","last_name":"Dierssen"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"department":[{"_id":"SiHi"}],"quality_controlled":"1","scopus_import":1,"abstract":[{"text":"Individuals with Down syndrome (DS) present important motor deficits that derive from altered motor development of infants and young children. DYRK1A, a candidate gene for DS abnormalities has been implicated in motor function due to its expression in motor nuclei in the adult brain, and its overexpression in DS mouse models leads to hyperactivity and altered motor learning. However, its precise role in the adult motor system, or its possible involvement in postnatal locomotor development has not yet been clarified. During the postnatal period we observed time-specific expression of Dyrk1A in discrete subsets of brainstem nuclei and spinal cord motor neurons. Interestingly, we describe for the first time the presence of Dyrk1A in the presynaptic terminal of the neuromuscular junctions and its axonal transport from the facial nucleus, suggesting a function for Dyrk1A in these structures. Relevant to DS, Dyrk1A overexpression in transgenic mice (TgDyrk1A) produces motor developmental alterations possibly contributing to DS motor phenotypes and modifies the numbers of motor cholinergic neurons, suggesting that the kinase may have a role in the development of the brainstem and spinal cord motor system.","lang":"eng"}]}