Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor

Pan B, Dong Y, Ito W, Yanagawa Y, Shigemoto R, Morozov A. 2009. Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor. Neuron. 61(6), 917–929.

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Journal Article | Published
Author
Pan, Bingxing; Dong, Yu-Lin; Ito, Wataru; Yanagawa, Yuchio; Shigemoto, RyuichiIST Austria ; Morozov, Alexei A
Abstract
GABAb receptor (GABAbR)-mediated suppression of glutamate release is critical for limiting glutamatergic transmission across the central nervous system (CNS). Here we show that, upon tetanic stimulation of afferents to lateral amygdala, presynaptic GABAbR-mediated inhibition only occurs in glutamatergic inputs to principle neurons (PNs), not to interneurons (INs), despite the presence of GABAbR in terminals to both types of neurons. The selectivity is caused by differential local GABA accumulation; it requires GABA reuptake and parallels distinct spatial distributions of presynaptic GABAbR in terminals to PNs and INs. Moreover, GABAbR-mediated suppression of theta-burst-induced long-term potentiation (LTP) occurs only in the inputs to PNs, not to INs. Thus, target-cell-specific control of glutamate release by presynaptic GABAbR orchestrates the inhibitory dominance inside amygdala and might contribute to prevention of nonadaptive defensive behaviors.
Publishing Year
Date Published
2009-03-26
Journal Title
Neuron
Volume
61
Issue
6
Page
917 - 929
IST-REx-ID

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Pan B, Dong Y, Ito W, Yanagawa Y, Shigemoto R, Morozov A. Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor. Neuron. 2009;61(6):917-929. doi:10.1016/j.neuron.2009.01.029
Pan, B., Dong, Y., Ito, W., Yanagawa, Y., Shigemoto, R., & Morozov, A. (2009). Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2009.01.029
Pan, Bingxing, Yu Dong, Wataru Ito, Yuchio Yanagawa, Ryuichi Shigemoto, and Alexei Morozov. “Selective Gating of Glutamatergic Inputs to Excitatory Neurons of Amygdala by Presynaptic GABAb Receptor.” Neuron. Elsevier, 2009. https://doi.org/10.1016/j.neuron.2009.01.029.
B. Pan, Y. Dong, W. Ito, Y. Yanagawa, R. Shigemoto, and A. Morozov, “Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor,” Neuron, vol. 61, no. 6. Elsevier, pp. 917–929, 2009.
Pan B, Dong Y, Ito W, Yanagawa Y, Shigemoto R, Morozov A. 2009. Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor. Neuron. 61(6), 917–929.
Pan, Bingxing, et al. “Selective Gating of Glutamatergic Inputs to Excitatory Neurons of Amygdala by Presynaptic GABAb Receptor.” Neuron, vol. 61, no. 6, Elsevier, 2009, pp. 917–29, doi:10.1016/j.neuron.2009.01.029.

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